Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain
文献类型：期刊论文
| 作者 | Ouyang, Qi1,2; Zhao, Fei1; Ye, Jingjing1; Xu, Mengyang1,2,3; Pu, Suyun4; Hui, Wenxue4; Gao, Xinyan4; Zha, Xiaochuan4; Chen, Hao5; Wang, Zhiming5 |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2024-11-14 |
| 页码 | 9 |
| 关键词 | molecular MRI rimonabant PET imaging [F-18]MK9470 in vivo imaging endocannabinoidsystem |
| ISSN号 | 1948-7193 |
| DOI | 10.1021/acschemneuro.4c00259 |
| 通讯作者 | Luo, Zonghua(luozh@shanghaitech.edu.cn) ; Thompson, Garth J.(contact@garththompson.com) |
| 英文摘要 | The cannabinoid 1 receptor (CB1) is highly expressed in the central nervous system, where its physiological functions include the regulation of energy balance, pain, and addiction. Herein, we develop and validate a technique to use magnetic resonance imaging (MRI) to investigate the distribution of CB1 across mouse brains with high spatial resolution, expanding previously described in vitro studies and in vivo studies with positron emission tomography (PET). To support the MRI investigations, we developed a ligand that is specific for in vivo neuroimaging of CB1. By chemically conjugating the CB1 antagonist rimonabant acid to a gadolinium chelator, we obtained the paramagnetic probe Rimota-Gd. The specificity of binding of rimonabant acid to CB1 and the relaxation enhancement by the paramagnetic gadolinium permit MRI-based localization of CB1. We used Rimota-Gd to investigate the spatial distribution of CB1 across the mouse brain and compared the results with an investigation using the PET radioligand [F-18]MK-9470. Rimota-Gd opens the door for in vivo MRI imaging of CB1 and provides a roadmap for the study of other receptors by whole-brain images with high spatial and temporal resolution. |
| WOS关键词 | RIMONABANT ; DENSITY ; TRACER |
| 资助项目 | ShanghaiTech University ; Shanghai Municipal Government ; National Natural Science Foundation of China[81950410637] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001355730300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314518]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Luo, Zonghua; Thompson, Garth J. |
| 作者单位 | 1.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 4.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 200031, Peoples R China 5.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Scripps Res Inst, Dept Integrated Struct & Computat Biol, La Jolla, CA 92037 USA 7.Swiss Fed Inst Technol, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland |
| 推荐引用方式 GB/T 7714 | Ouyang, Qi,Zhao, Fei,Ye, Jingjing,et al. Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain[J]. ACS CHEMICAL NEUROSCIENCE,2024:9. |
| APA | Ouyang, Qi.,Zhao, Fei.,Ye, Jingjing.,Xu, Mengyang.,Pu, Suyun.,...&Thompson, Garth J..(2024).Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain.ACS CHEMICAL NEUROSCIENCE,9. |
| MLA | Ouyang, Qi,et al."Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain".ACS CHEMICAL NEUROSCIENCE (2024):9. |
入库方式： OAI收割
来源：上海药物研究所
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