EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer
文献类型：期刊论文
| 作者 | Zhou, Mengxue5; Zhou, Chuang4,5; Geng, Huan3; Huang, Zhiwei1; Lin, Zhiyuan5; Wang, Ying5; Zhu, Yin5; Shi, Jiang5; Tan, Junfeng5; Guo, Li5 |
| 刊名 | SMALL
 |
| 出版日期 | 2024-11-19 |
| 页码 | 20 |
| 关键词 | chemo/chemodynamic therapy EGCG nanomedicine TGF-beta signaling triple-negative breast cancer |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202406245 |
| 通讯作者 | Dai, Weidong(daiweidong@tricaas.com) ; Lv, Haipeng(lvhaipeng@tricaas.com) ; Lin, Zhi(linz@tricaas.com) |
| 英文摘要 | The presence of dense collagen fibers is a typical characteristic of triple-negative breast cancer (TNBC). Although these fibers hinder drug penetration and reduce treatment efficacy, the depletion of the collagen matrix is associated with tumor metastasis. To address this issue, epigallocatechin-3-gallate (EGCG) is first exploited for disrupting the dense collagenous stroma and alleviate fibrosis by specifically blocking the TGF-beta/Smad pathway in fibroblasts and tumor cells when intraperitoneally administrated in TNBC tumor-bearing mice. A methotrexate (MTX)-loaded dual phosphate- and pH-responsive nanodrug (pHA@MOF-Au/MTX) is next engineered by integrating Fe-based metal-organic frameworks and gold nanoparticles for improved chemo/chemodynamic therapy of TNBC. Surface modification with pH (low)-insertion peptide substantially enhanced the binding of the nanodrug to 4T1 cells owing to tumor stroma remodeling by EGCG. High-concentration EGCG inhibited glutathione peroxidase by regulating mitochondrial glutamine metabolism, thus facilitating tumor cell ferroptosis. Furthermore, sequential EGCG and pHA@MOF-Au/MTX treatment showed remarkable anti-tumor effects in a mouse model of TNBC, with a tumor growth inhibition rate of 79.9%, and a pulmonary metastasis rate of 96.8%. Altogether, the combination strategy developed in this study can improve the efficacy of chemo/chemodynamic therapy in TNBC and represents an innovative application of EGCG. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; BETA ; (-)-EPIGALLOCATECHIN-3-GALLATE ; NANOPARTICLES ; RESISTANCE ; STROMA ; LUNG |
| 资助项目 | Central Public-interest Scientific Institution Basal Research Fund ; Zhejiang Province Basic Public Welfare Research Project[LQ24H180001] ; National Natural Science Foundation of China[82402467] ; Key Research and Development Program of Zhejiang[2023C02040] ; Zhejiang Provincial Outstanding Youth Science Foundation[LR23C160002] ; Special Funds for China Agriculture Research System of MOF[CARS-19] ; Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences[CAAS-ASTIP-2014-TRICAAS] ; [1610212022005] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001357858800001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314530]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Weidong; Lv, Haipeng; Lin, Zhi |
| 作者单位 | 1.Lanzhou Univ, Frontiers Sci Ctr Rare Isotopes, MOE, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Zhejiang Univ, Affiliated Hosp 2, Dept Orthoped Surg, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China 4.Shaanxi Univ Sci & Technol, Sch Food & Biol Engn, Xian 710021, Peoples R China 5.Chinese Acad Agr Sci, Tea Res Inst, Key Lab Tea Biol & Resource Utilizat, Minist Agr, Hangzhou 310008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Mengxue,Zhou, Chuang,Geng, Huan,et al. EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer[J]. SMALL,2024:20. |
| APA | Zhou, Mengxue.,Zhou, Chuang.,Geng, Huan.,Huang, Zhiwei.,Lin, Zhiyuan.,...&Lin, Zhi.(2024).EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer.SMALL,20. |
| MLA | Zhou, Mengxue,et al."EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer".SMALL (2024):20. |
入库方式： OAI收割
来源：上海药物研究所
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