The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis
文献类型：期刊论文
| 作者 | Huang, Qian1,4; An, Ziming1; Xin, Xin1; Gou, Xiaojun2; Tian, Xiaoting3; Hu, Yiyang1; Mei, Zubing8; Feng, Qin1,5,6,7 |
| 刊名 | FOOD SCIENCE & NUTRITION
 |
| 出版日期 | 2024-11-14 |
| 页码 | 20 |
| 关键词 | curcumin meta-analysis metabolic dysfunction-associated steatotic liver disease resveratrol silymarin |
| ISSN号 | 2048-7177 |
| DOI | 10.1002/fsn3.4595 |
| 通讯作者 | Mei, Zubing(herrmayor@shutcm.edu.cn) ; Feng, Qin(fengqin@shutcm.edu.cn) |
| 英文摘要 | Polyphenols, known for their potent antioxidant and anti-inflammatory properties, have emerged as promising, natural, and safe complementary treatment options for metabolic-associated steatotic liver disease (MASLD). Among these, curcumin, resveratrol, and silymarin are the most extensively studied; however, their differential effects on MASLD outcomes remain inconclusive. This systematic review and meta-analysis of RCTs aimed to evaluate the efficacy of curcumin, resveratrol, and silymarin in patients with MASLD. A comprehensive search of seven databases was conducted up to September 2024. Odds ratios (OR), mean differences (MD), and standardized MD (SMD) with 95% confidence intervals (CI) were used to assess treatment effects. Primary outcomes included improvement in hepatic steatosis and ALT activity, while secondary outcomes included changes in AST activity, blood lipids, glucose, BMI, blood pressure, and TNF-alpha. Twenty-seven studies involving 1691 participants were included. Curcumin significantly improved hepatic steatosis compared to placebo (OR: 4.39, 95% CI: 1.45 to 13.27, p = 0.009), followed by resveratrol (OR: 3.18, 95% CI: 1.20 to 8.42, p = 0.02). Silymarin exhibited the strongest effect in reducing ALT levels (MD: -6.44 U/L, 95% CI: -10.03 to -2.85, p = 0.0004), with curcumin (MD: -5.88 U/L, 95% CI: -9.05 to -2.72, p = 0.0003) also showing significant reductions. A marked reduction in AST was observed with silymarin (MD: -6.99 U/L, 95% CI: -8.56 to -5.42, p < 0.00001), followed by curcumin (MD: -3.36 U/L, 95% CI: -5.35 to -1.36, p = 0.001). Furthermore, curcumin intake significantly improved metabolic indicators (TG, FBG, HOMA-IR, and BMI). Resveratrol reduced FBG and DBP. Curcumin had the strongest effect on hepatic steatosis and improved both transaminase levels and metabolic markers. Silymarin demonstrated the greatest reduction in transaminase levels, while resveratrol showed modest benefits in steatosis and metabolic improvements. The three polyphenols appear as promising therapeutics for the treatment of MASLD. |
| WOS关键词 | FATTY LIVER-DISEASE ; CELLS IN-VITRO ; INSULIN-RESISTANCE ; CONTROLLED-TRIAL ; GENE-EXPRESSION ; DOUBLE-BLIND ; KAPPA-B ; SUPPLEMENTATION ; STEATOSIS ; POLYPHENOLS |
| 资助项目 | Shanghai Shenkang 3-year action plan |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001358141200001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314595]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mei, Zubing; Feng, Qin |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai, Peoples R China 2.Baoshan Dist Hosp Integrated Tradit Chinese & West, Cent Lab, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 4.Shaanxi Univ Chinese Med, Sch Basic Med, Xianyang, Shaanxi, Peoples R China 5.Shanghai Univ Chinese Tradit Med, Shuguang Hosp, Cent Lab, Shanghai, Peoples R China 6.Shanghai Univ Tradit Chinese Med, Key Lab Liver & Kidney Dis, Minist Educ, Shanghai, Peoples R China 7.Shanghai Key Lab Tradit Chinese Clin Med, Shanghai, Peoples R China 8.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Anorectal Dis, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Qian,An, Ziming,Xin, Xin,et al. The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis[J]. FOOD SCIENCE & NUTRITION,2024:20. |
| APA | Huang, Qian.,An, Ziming.,Xin, Xin.,Gou, Xiaojun.,Tian, Xiaoting.,...&Feng, Qin.(2024).The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis.FOOD SCIENCE & NUTRITION,20. |
| MLA | Huang, Qian,et al."The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis".FOOD SCIENCE & NUTRITION (2024):20. |
入库方式： OAI收割
来源：上海药物研究所
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