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The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives

文献类型：期刊论文

作者Peng, Cheng1; Sheng, Li2; Xu, Gao-Ya2; Qi, Xiao-Lei1; Zhou, Yu-Bo2; Jia-Li2; Cui, Yong-Mei1
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2025
卷号115页码:6
关键词Antileukemic Thiazolyl Urea Synthesis SAR
ISSN号0960-894X
DOI10.1016/j.bmcl.2024.130018
通讯作者Jia-Li(jli@simm.ac.cn) ; Cui, Yong-Mei(ymcui@shu.edu.cn)
英文摘要A series of novel 5-substituted thiazolyl urea derivatives were synthesized and evaluated for their efficacy as antileukemic agents against two human leukemic cell lines (THP-1 and MV-4-11). Results showed that the activities of the investigated compounds were quite sensitive to the positions and properties of the aromatic substituents. Among these compounds, compound 12k showed the highest activity with IC50 values of 29 +/- 0.3 nM for THP-1 cells and 98 +/- 10 nM for MV-4-11 cells.
资助项目Science and Technology Commission of Shanghai Municipality[19ZR1419700]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:001361267500001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/314665]  
专题中国科学院上海药物研究所
通讯作者Jia-Li; Cui, Yong-Mei
作者单位1.Shanghai Univ, Coll Sci, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Peng, Cheng,Sheng, Li,Xu, Gao-Ya,et al. The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2025,115:6.
APA Peng, Cheng.,Sheng, Li.,Xu, Gao-Ya.,Qi, Xiao-Lei.,Zhou, Yu-Bo.,...&Cui, Yong-Mei.(2025).The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,115,6.
MLA Peng, Cheng,et al."The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 115(2025):6.

入库方式： OAI收割

来源：上海药物研究所

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