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Direct aminosulfonylation of electron-rich (hetero)arenes utilizing tert-butyl chlorosulfonylcarbamate and diisopropylethylamine

文献类型：期刊论文

作者Zhang, Xiaofei2; Tan, Jiangtao2,3; Zhong, Yuancheng2; Zhuang, Zhen2,3; He, Qian2; Jiang, Min1; Yang, Chunhao2,3
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2024-11-19
页码8
ISSN号2052-4129
DOI10.1039/d4qo01731e
通讯作者Jiang, Min(jiangm263@163.com) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要Sulfonamides, especially primary aryl sulfonamides, are very important scaffolds not only because of their wide applications as pharmacophores in drugs, but also their derivatization into other sulfonamides and different sulfur-containing compounds. Among aryl sulfonamides, most syntheses of electron-rich (hetero)aryl sulfonamides are still severely limited by the classic chlorosulfonation or oxidative chlorination reactions with significant drawbacks. In this work, using the proposed and unique tert-butyl sulfonylcarbamate intermediate generated in situ from easily accessible tert-butyl chlorosulfonylcarbamate and diisopropylethylamine, a catalyst-free, mild and very practical aminosulfonylation protocol for a wide range of electron-rich (hetero)arene substrates with good to excellent yields was reported.
WOS关键词N-SULFONYLAMINES ; SULFONAMIDES ; INHIBITOR ; POLYMERIZATION ; SULFONATION ; ACID ; ARYL
资助项目State Key Laboratory of Drug Research[LG202103-01-06] ; [SKLDR-2023-KF-06]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001363497900001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/314668]  
专题中国科学院上海药物研究所
通讯作者Jiang, Min; Yang, Chunhao
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Ruijin Hosp,De, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xiaofei,Tan, Jiangtao,Zhong, Yuancheng,et al. Direct aminosulfonylation of electron-rich (hetero)arenes utilizing tert-butyl chlorosulfonylcarbamate and diisopropylethylamine[J]. ORGANIC CHEMISTRY FRONTIERS,2024:8.
APA Zhang, Xiaofei.,Tan, Jiangtao.,Zhong, Yuancheng.,Zhuang, Zhen.,He, Qian.,...&Yang, Chunhao.(2024).Direct aminosulfonylation of electron-rich (hetero)arenes utilizing tert-butyl chlorosulfonylcarbamate and diisopropylethylamine.ORGANIC CHEMISTRY FRONTIERS,8.
MLA Zhang, Xiaofei,et al."Direct aminosulfonylation of electron-rich (hetero)arenes utilizing tert-butyl chlorosulfonylcarbamate and diisopropylethylamine".ORGANIC CHEMISTRY FRONTIERS (2024):8.

入库方式： OAI收割

来源：上海药物研究所

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