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Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetinmediated leverage of glycolysis and OXPHOS

文献类型：期刊论文

作者Zhang, Yi1,4; Shi, Junyu1; Zhu, Jie4; Ding, Xinxin1; Wei, Jianxu1; Jiang, Xue1; Yang, Yijie1; Zhang, Xiaomeng1; Huang, Yongzhuo2,3,4; Lai, Hongchang1
刊名ACTA PHARMACEUTICA SINICA B
出版日期2024-11-01
卷号14期号:11页码:5026-5036
关键词Quercetin Periodontitis Macrophage Glycolysis Oxidative phosphorylation (OXPHOS) Mesoporous polydopamine Mitochondrial reactive oxygen species Immunometabolic rewiring
ISSN号2211-3835
DOI10.1016/j.apsb.2024.07.008
通讯作者Zhang, Xiaomeng(119039@sh9hospital.org.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Lai, Hongchang(laihongchang@sjtu.edu.cn)
英文摘要Periodontitis is a chronic inflammatory disease marked by a dysregulated immune microenvironment, posing formidable challenges for effective treatment. The disease is characterized by an altered glucose metabolism in macrophages, specifically an increase in aerobic glycolysis, which is linked to heightened inflammatory responses. This suggests that targeting macrophage metabolism could offer a new therapeutic avenue. In this study, we developed an immunometabolic intervention using quercetin (Q) encapsulated in bioadhesive mesoporous polydopamine (Q@MPDA) to treat periodontitis. Our results demonstrated that Q@MPDA could reprogram inflammatory macrophages to an antiinflammatory phenotype ( i.e. , from-M1-to-M2 repolarization). In a murine periodontitis model, locally administered Q@MPDA reduced the presence of inflammatory macrophages, and decreased the levels of inflammatory cytokines (IL-1b and TNF-a) and reactive oxygen species (ROS) in the periodontium. Consequently, it alleviated periodontitis symptoms, reduced alveolar bone loss, and promoted tissue repair. Furthermore, our study revealed that Q@MPDA could inhibit the glycolysis of inflammatory macrophages while enhancing oxidative phosphorylation (OXPHOS), facilitating the shift from M1 to M2 macrophage subtype. Our findings suggest that Q@MPDA is a promising treatment for periodontitis via immunometabolic rewiring. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词OXIDATIVE STRESS ; CROSSTALK ; TUMOR
资助项目National Key Research and Development Program of China, China[2022YFE0203600] ; National Nature Science Foundation of China[82271028] ; Department of Science and Technology of Guangdong Province (High-level New R&D Institute, China)[2019B090904008] ; Department of Science and Technology of Guangdong Province (High-level Innovative Research Institute, China)[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology, China[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology, China[CXTD2022011] ; Project of Biobank, China[YBKB202102] ; Research Discipline Fund, China[KQYJXK2020] ; Cross-disciplinary Research Fund, China[JYJC202205] ; Shanghai Ninth People's Hospital, China[SHSMU-ZDCX20212500] ; Shanghai Pujiang Program, China[22PJD038] ; [82341232]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001363518700001
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/314686]  
专题新药研究国家重点实验室
通讯作者Zhang, Xiaomeng; Huang, Yongzhuo; Lai, Hongchang
作者单位1.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Oral Dis, Shanghai Key Lab Stomatol,Shanghai Peoples Hosp 9, Dept Implant Dent,Coll Stomatol,Sch Med, Shanghai 200011, Peoples R China
2.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yi,Shi, Junyu,Zhu, Jie,et al. Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetinmediated leverage of glycolysis and OXPHOS[J]. ACTA PHARMACEUTICA SINICA B,2024,14(11):5026-5036.
APA Zhang, Yi.,Shi, Junyu.,Zhu, Jie.,Ding, Xinxin.,Wei, Jianxu.,...&Lai, Hongchang.(2024).Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetinmediated leverage of glycolysis and OXPHOS.ACTA PHARMACEUTICA SINICA B,14(11),5026-5036.
MLA Zhang, Yi,et al."Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetinmediated leverage of glycolysis and OXPHOS".ACTA PHARMACEUTICA SINICA B 14.11(2024):5026-5036.

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来源：上海药物研究所

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