Golgi-derived extracellular vesicle production induced by SARS-CoV-2 envelope protein
文献类型：期刊论文
| 作者 | Li, Qiguang1,2; Liu, Qian2; Li, Shuangqu1,2; Zuo, Xiaoli2; Zhou, Hu1,2 ; Gao, Zhaobing1,2,3; Xia, Bingqing1,2
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| 刊名 | APOPTOSIS
 |
| 出版日期 | 2024-11-23 |
| 页码 | 13 |
| 关键词 | Extracellular vesicle SARS-CoV-2 Envelope protein Ion channel Golgi fragmentation |
| ISSN号 | 1360-8185 |
| DOI | 10.1007/s10495-024-02035-3 |
| 通讯作者 | Zhou, Hu(zhouhu@simm.ac.cn) ; Gao, Zhaobing(zbgao@simm.ac.cn) ; Xia, Bingqing(xiabingqing@simm.ac.cn) |
| 英文摘要 | Extracellular vesicles facilitate cell-to-cell communication, and some enveloped viruses utilize these vesicles as carriers to mediate viral transmission. SARS-CoV-2 envelope protein (2-E) forms a cation channel and overexpression of 2-E led to the generation of a distinct type of large extracellular vesicles (2-E-EVs). Although 2-E-EVs have been demonstrated to facilitate viral transmission in a receptor-independent way, the characteristics and biogenesis mechanism remain enigmatic. Via lipidomics and proteomic analysis, we found 2-E-EVs are distinct from endosome-derived exosomes. 2-E-EVs are notably enriched in Golgi apparatus components, aligning with the observed fragmentation in Golgi morphology. Through live cell imaging, we established a connection between 2-E-EVs formation, Golgi fragmentation, and channel activity, emphasizing the role of 2-E-EVs as ion channel-induced extracellular vesicles. Our work highlights 2-E-EVs as distinctive Golgi-derived vesicles, contributing to a deeper understanding of 2-E channel-mediated virus-host dynamics, with implications for therapeutic strategies and drug delivery. |
| WOS关键词 | VIRUS ; FRAGMENTATION ; AUTOPHAGY ; APPARATUS ; EXOSOMES ; CLEAVAGE |
| 资助项目 | National Natural Science Foundation of China[81825021] ; National Science Fund of Distinguished Young Scholars[92169202,82341058] ; National Natural Science Foundation of China[2020YFC0842000] ; National Key Research and Development Program of China[LG202101-01-04] ; National Key Laboratory Program of China[20ZR1474200] ; National Key Laboratory Program of China[22QA1411000] ; Fund of Shanghai Science and Technology |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001361442400001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314692]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Hu; Gao, Zhaobing; Xia, Bingqing |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery Innovat, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiguang,Liu, Qian,Li, Shuangqu,et al. Golgi-derived extracellular vesicle production induced by SARS-CoV-2 envelope protein[J]. APOPTOSIS,2024:13. |
| APA | Li, Qiguang.,Liu, Qian.,Li, Shuangqu.,Zuo, Xiaoli.,Zhou, Hu.,...&Xia, Bingqing.(2024).Golgi-derived extracellular vesicle production induced by SARS-CoV-2 envelope protein.APOPTOSIS,13. |
| MLA | Li, Qiguang,et al."Golgi-derived extracellular vesicle production induced by SARS-CoV-2 envelope protein".APOPTOSIS (2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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