On-DNA Three-Component Cycloaddition of Diazo Compounds, Nitrosoarenes, and Alkenes: Syntheses of Isoxazolidines for DNA-Encoded Chemical Libraries
文献类型：期刊论文
| 作者 | Fu, Xiang1,3; Li, Yaxin1; He, Mingjin2; Ren, Junxin1; Wei, Zinan1; Kang, Zhenghui2; Hu, Wenhao1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-11-25 |
| 卷号 | 26期号:48页码:10376-10381 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c04011 |
| 通讯作者 | Kang, Zhenghui(kangzhenghui@simm.ac.cn) ; Hu, Wenhao(huwh9@mail.sysu.edu.cn) |
| 英文摘要 | A DNA-compatible three-component reaction is disclosed for the synthesis of on-DNA polysubstituted isoxazolidines that serve as privileged core scaffolds in numerous natural products and bioactive molecules. This one-pot approach involves the 1,3-dipolar cycloaddition of DNA-tagged styrenes with diazo compounds and nitrosoarenes in an aqueous solution of KOAc. The reaction demonstrates excellent functional group compatibility, providing a conventional protocol for the construction of a DNA-labeled isoxazolidine library. |
| WOS关键词 | 1,3-DIPOLAR CYCLOADDITION |
| 资助项目 | National Natural Science Foundation of China[92256301] ; National Natural Science Foundation of China[92056201] ; National Natural Science Foundation of China[2023B1212060022] ; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery[2024A1515030037] ; Natural Science Foundation of Guangdong Province[2022B1111050003] ; Key-Area Research and Development Program of Guangdong Province |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001362808700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314701]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Kang, Zhenghui; Hu, Wenhao |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, State Key Lab Antiinfect Drug Discovery & Dev, Guangzhou 510006, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Yantai Univ, Basic Sci Res Ctr Base Pharmaceut Sci, Yantai 264005, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiang,Li, Yaxin,He, Mingjin,et al. On-DNA Three-Component Cycloaddition of Diazo Compounds, Nitrosoarenes, and Alkenes: Syntheses of Isoxazolidines for DNA-Encoded Chemical Libraries[J]. ORGANIC LETTERS,2024,26(48):10376-10381. |
| APA | Fu, Xiang.,Li, Yaxin.,He, Mingjin.,Ren, Junxin.,Wei, Zinan.,...&Hu, Wenhao.(2024).On-DNA Three-Component Cycloaddition of Diazo Compounds, Nitrosoarenes, and Alkenes: Syntheses of Isoxazolidines for DNA-Encoded Chemical Libraries.ORGANIC LETTERS,26(48),10376-10381. |
| MLA | Fu, Xiang,et al."On-DNA Three-Component Cycloaddition of Diazo Compounds, Nitrosoarenes, and Alkenes: Syntheses of Isoxazolidines for DNA-Encoded Chemical Libraries".ORGANIC LETTERS 26.48(2024):10376-10381. |
入库方式： OAI收割
来源：上海药物研究所
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