Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates
文献类型：期刊论文
| 作者 | Wang, Yicong1,2,4,5; Lu, Wenhan3; Chen, Zi-Han9; Xiao, Yan1,2,4,5; Wang, Yu1,2,4,5; Gao, Wenhao1,2,4,5; Wang, Zhiming8; Song, Ruihu8; Fang, Zhao8; Hu, Wei1,2,4,5 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2024-12-18 |
| 页码 | 13 |
| 关键词 | biomaterials follicular tracking multi-color imaging near-infrared II bioconjugates near-infrared II in vivo imaging |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202414129 |
| 通讯作者 | Chen, Hao(haoc@simm.ac.cn) ; Feng, Yi(fengyi17@fudan.edu.cn) |
| 英文摘要 | Follicular tracking is typically conducted using ultrasound technology, but its effectiveness is constrained by limited resolution. High-resolution imaging of deep tissues can be accomplished using luminescence imaging in the near-infrared II window (NIR-II, 1000-1700 nm); however, the contrast agents that are used lack specificity. Here, it is reported that the FDA-approved indocyanine green (ICG)-conjugated recombinant human chorionic gonadotropin (hCG) protein can target early follicles with long-term effectiveness. A novel high-resolution NIR-II imaging approach is developed for monitoring follicular development as well as ovulation using multi-color imaging of ovarian vessels with a combination of non-overlapping downconversion nanoparticles (DCNPs). The results showed that the ability to monitor early follicles of around 50 mu m in diameter exceeded the spatial and temporal resolution of ultrasound or MRI without the reproductive damage associated with computed tomography radiation, and this enabled the clinical identification of the follicular reserve in patients with infertility diseases such as polycystic ovary syndrome (PCOS). In addition, NIR-II imaging clearly targeted ovarian tumors and showed micro-metastatic lesions, thus providing a new tool for monitoring tumors in vivo and guiding surgical resection. |
| WOS关键词 | LUTEINIZING-HORMONE RECEPTOR ; POLYCYSTIC-OVARY ; LOCALIZATION ; EXPRESSION |
| 资助项目 | Development Project of Shanghai Peak Disciplines-Integrated Chinese and Western Medicine ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; National Natural Science Foundation of China[NSFC 81973945] ; National Natural Science Foundation of China[82174497] ; Innovative Research Team of High-Level Local Universities in Shanghai ; [20180101] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001379709700001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315145]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Hao; Feng, Yi |
| 作者单位 | 1.Fudan Univ, Sch Basic Med Sci, Brain Sci Collaborat Innovat Ctr,Shanghai Med Coll, Dept Integrat Med & Neurobiol,State Key Lab Med Ne, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China 3.Fudan Univ, Eye & ENT Hosp, Shanghai Med Coll, Dept Ophthalmol & Visual Sci, 83 Fenyang Rd, Shanghai 200031, Peoples R China 4.Fudan Zhangjiang Inst, Shanghai 201203, Peoples R China 5.Shanghai Inst Acupuncture & Moxibust, Shanghai Key Lab Acupuncture Mech & Acupoint Funct, Shanghai 200433, Peoples R China 6.Fudan Univ, Shanghai Canc Ctr, Dept Nucl Med, Shanghai 200032, Peoples R China 7.Fudan Univ, Shanghai Ji Ai Genet & IVF Inst, Shanghai Key Lab Female Reprod Endocrine Related D, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 9.Fudan Univ, Dept Chem, State Key Lab Mol Engn Polymers & iChem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yicong,Lu, Wenhan,Chen, Zi-Han,et al. Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates[J]. ADVANCED MATERIALS,2024:13. |
| APA | Wang, Yicong.,Lu, Wenhan.,Chen, Zi-Han.,Xiao, Yan.,Wang, Yu.,...&Feng, Yi.(2024).Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates.ADVANCED MATERIALS,13. |
| MLA | Wang, Yicong,et al."Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates".ADVANCED MATERIALS (2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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