Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP-Citrate Lyase and Acetyl-CoA Carboxylase
文献类型：期刊论文
| 作者 | Zhao, Ze-Yu3,4; Zang, Yi1 ; Li, Jia1; Choo, Yeun-Mun2; Xiong, Juan3; Hu, Jin-Feng3,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2024-12-01 |
| 卷号 | 21期号:12页码:7 |
| 关键词 | Keteleeria hainanensis Pinaceae Fortunefuroic acid ATP-citrate lyase Acetyl-CoA carboxylase 1 Natural products Terpenoids |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202401520 |
| 通讯作者 | Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn) |
| 英文摘要 | A previously undescribed triterpenoid (fortunefuroic acid J, 1) was isolated from the endangered conifer Keteleeria hainanensis, along with 20 other known terpenoids. Compound 1 is characterized by an unusual 3,4-seco-9 beta H-lanost-3-oic acid motif, featuring a rare furoic acid moiety in its lateral chain. The structure elucidation of this compound was achieved through a combination of spectroscopic and computational methods. The C-15 epimers of 15-methoxypinusolidic acid (15R-8 and 15S-9) were successfully separated and identified for the first time. Compound 1 demonstrated dual inhibitory effects against ATP-citrate lyase (ACL, IC50: 0.92 mu M) and acetyl-CoA carboxylase 1 (ACC1, IC50: 10.76 mu M). Compounds 2 and 11 exclusively inhibited ACL, exhibiting IC50 values of 2.64 and 6.35 mu M, respectively. Compound 1 is classified among the fortunefuroic acid-type compounds, previously isolated from K. fortunei, distinguished by the presence of a rare furoic acid moiety in their lateral chain. The chemotaxonomic significance of the 9 beta H-lanost-26-oic acids in Keteleeria was briefly discussed. These findings highlight the importance of conserving plant species diversity, thereby enhancing the exploration of structurally diverse compounds and potential avenues for developing new therapeutics targeting ACL/ACC1-associated diseases. |
| WOS关键词 | COMPLETE CHLOROPLAST GENOME ; CHEMICAL-CONSTITUENTS ; TRITERPENOIDS ; DERIVATIVES ; PRODUCTS ; LEAVES |
| 资助项目 | NSFC[21937002] ; NSFC[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001377210500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315148]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiong, Juan; Hu, Jin-Feng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Malaya, Chem Dept, Fac Sci, Kuala Lumpur 50603, Malaysia 3.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 4.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & C, Taizhou 318000, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ze-Yu,Zang, Yi,Li, Jia,et al. Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP-Citrate Lyase and Acetyl-CoA Carboxylase[J]. CHEMISTRY & BIODIVERSITY,2024,21(12):7. |
| APA | Zhao, Ze-Yu,Zang, Yi,Li, Jia,Choo, Yeun-Mun,Xiong, Juan,&Hu, Jin-Feng.(2024).Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP-Citrate Lyase and Acetyl-CoA Carboxylase.CHEMISTRY & BIODIVERSITY,21(12),7. |
| MLA | Zhao, Ze-Yu,et al."Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP-Citrate Lyase and Acetyl-CoA Carboxylase".CHEMISTRY & BIODIVERSITY 21.12(2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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