5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy
文献类型：期刊论文
| 作者 | Sun, Xujie1,2,3; Shan, Xiaoting1,2; Zhu, Binyu1,2; Cai, Ying1,2; He, Zongyan3; Zhou, Lingli1,2; Yin, Lixuan3; Liu, Yiran3; Liu, Kaiyue3; Zhang, Tian3 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2024-12-15 |
| 页码 | 13 |
| 关键词 | 5-fluorouracil colorectal cancer gut microbiota prebiotics xylan |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.202403587 |
| 通讯作者 | Li, Yaping(ypli@simm.ac.cn) ; Lang, Tianqun(langtq@lglab.ac.cn) |
| 英文摘要 | The gut microbiota exerts inhibitory effects on the occurrence and progression of colorectal cancer (CRC) through various mechanisms. Compared to traditional microbiota regulation methods, prebiotics and probiotics demonstrate significant advantages in terms of safety and patient adaptability. Their synergy not only improves the intestinal environment but also enhances the host's anti-tumor immune response. 5-Fluorouracil (5-FU) is a first-line chemotherapy drug that has a short half-life and low bioavailability. However, if administered in an untargeted manner, 5-FU also causes adverse reactions. Liposomes can improve the pharmacokinetic profile of drugs and provide targeted delivery to the tumor site, thereby reducing side effects. In this work, a 5-FU-loaded liposome is modified with the prebiotic xylan derivative Sxy and the probiotic Akkermansia muciniphila active phospholipid homolog 1,2-dipalmitoylphosphatidy-lethanolamine (DPPE) to construct FLSK. The latter effectively prolongs the intestinal transport and release of 5-FU, maintaining high drug concentrations at the tumor site. FLSK is found to inhibit tumor growth and significantly extends the survival period of mice. In addition, FLSK promotes anti-tumor immunity and regulation of the gut microbiota. Combining the merits of prebiotics and probiotics, FLSK provides a potential strategy for integrating chemotherapy with gut microbiota regulation therapy for the treatment of CRC. |
| WOS关键词 | DELIVERY ; THERAPY |
| 资助项目 | National Key R&D Program of China ; Lingang Laboratory (Startup Fund), Shanghai Post-doctoral Excellence Program[2023017] ; Science and Technology Innovation Action Plan Sailing Plan of Shanghai[22YF1460500] ; [2022YFC3401404] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001378511000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315154]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yaping; Lang, Tianqun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Lingang Lab, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xujie,Shan, Xiaoting,Zhu, Binyu,et al. 5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy[J]. ADVANCED HEALTHCARE MATERIALS,2024:13. |
| APA | Sun, Xujie.,Shan, Xiaoting.,Zhu, Binyu.,Cai, Ying.,He, Zongyan.,...&Lang, Tianqun.(2024).5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy.ADVANCED HEALTHCARE MATERIALS,13. |
| MLA | Sun, Xujie,et al."5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy".ADVANCED HEALTHCARE MATERIALS (2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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