Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions
文献类型：期刊论文
| 作者 | Li, Jiuling2,3; Jia, Xinyu3; Yang, Qiangguo1,4; Guo, Jiakang2; Ren, Qianhui2; Liu, Taichen3; Wei, Kai2; Kang, Zhenghui1,4 |
| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2024-12-18 |
| 页码 | 6 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d4qo02118e |
| 通讯作者 | Li, Jiuling(orgchem90@163.com) ; Kang, Zhenghui(kangzhenghui@simm.ac.cn) |
| 英文摘要 | An environmentally-friendly and safe method has been developed to synthesize 1,5-disubstituted 1,2,3-triazoles containing difluoromethyl fragments, which can be obtained from readily available 2,2-difluoroarylethylamines under azide-free conditions. The classic conversion mode of acetic acid with tert-butyl nitrite is the critical factor in this reaction, allowing the diazo species generated in situ to immediately react with the raw materials to give the desired products in good yields. The mild reaction conditions and convenient operation not only make such an approach an attractive alternative method for the synthesis of polysubstituted 1,2,3-triazoles but also further promote the applications of 2,2-difluoroarylethylamines in organic synthesis. |
| WOS关键词 | CLICK CHEMISTRY ; 1,3-DIPOLAR CYCLOADDITIONS ; METAL-FREE ; LIGATION ; ALKYNES ; AMINES |
| 资助项目 | Natural Science Foundation of Guangdong Province[2024A1515030037] ; Natural Science Foundation of Guangdong Province[232102310372] ; Science and Technology Public Relations Project of Henan Province |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001381736200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315157]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Jiuling; Kang, Zhenghui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 2.Pingdingshan Univ, Sch Med Sci, Pingdingshan 467000, Peoples R China 3.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Guilin 541004, Peoples R China 4.Guizhou Med Univ, Sch Pharm, Guiyang 550014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiuling,Jia, Xinyu,Yang, Qiangguo,et al. Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions[J]. ORGANIC CHEMISTRY FRONTIERS,2024:6. |
| APA | Li, Jiuling.,Jia, Xinyu.,Yang, Qiangguo.,Guo, Jiakang.,Ren, Qianhui.,...&Kang, Zhenghui.(2024).Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions.ORGANIC CHEMISTRY FRONTIERS,6. |
| MLA | Li, Jiuling,et al."Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions".ORGANIC CHEMISTRY FRONTIERS (2024):6. |
入库方式： OAI收割
来源：上海药物研究所
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