De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques
文献类型：期刊论文
| 作者 | Gao, Jialu2,3,4; Zhu, Hua5; Cai, Huanhuan4; Ding, Qihang1,4; Xiong, Xiaoxing5; Zhang, Tong4; Chen, Bo4; Wang, Wumei4,7; Ju, Xinpeng4,7; Huang, Jianying4 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2025 |
| 卷号 | 503页码:13 |
| 关键词 | siRNA delivery Atheromatous plaques NIR-II imaging Multifunctional nanoplatform Epsin1/2 |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2024.158455 |
| 通讯作者 | Zeng, Xiaodong(xdzeng@baridd.ac.cn) ; Kim, Jong Seung(jongskim@korea.ac.kr) ; Hong, Xuechuan(Xhy78@whu.edu.cn) |
| 英文摘要 | Reducing foam cell formation and accumulation within plaques is a critical strategy for treating atherosclerosis. Although current lipid-lowering therapies have significantly improved the management of atherosclerosis, the risk of cardiovascular events remains. Thus, it is necessary to explore next-generation therapies to reduce foam cell formation, inflammation, and oxidative stress. To address these challenges, we present an innovative near- infrared II (NIR-II) fluorescent dye coupled with a lesion-targeting peptide, forming a molecular self-assembly nanoplatform for effective in vitro small interfering RNA (siRNA) delivery. This platform downregulates Epsin1/2, a family of ubiquitin-binding endocytic adaptors, upregulates the expressions of ABCG1 and LRP-1 proteins, and markedly reduces foam cell formation. Additionally, this system enables real-time tracking of plaque accumulation, therapeutic response, and efficacy through in vivo noninvasive NIR-II imaging. Systemic siRNA delivery significantly suppresses lipid accumulation, plaque size, and necrotic core area in the carotid plaque model of ApoE-/- mice. These results suggest that this multi-functional nanoplatform could become an effective tool for NIR-II image-guided siRNA delivery for personalized treatment of atherosclerosis. |
| WOS关键词 | CHOLESTEROL EFFLUX ; ARTERY PLAQUES ; IN-VIVO ; DELIVERY ; NANOPARTICLES ; INFLAMMATION |
| 资助项目 | Foundation of Shandong Province[ZR2023MB085] ; Shandong Labora-tory Program[SYS202205] ; Taishan Scholar Project[tsqn202306320] ; Special Project for Significant New Drug Research and Development in the Major National Science and Technology Pro-jects of China[2020ZX09201007] ; National Research Foundation of Korea[2018R1A3B1052702] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001383854800001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315169]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zeng, Xiaodong; Kim, Jong Seung; Hong, Xuechuan |
| 作者单位 | 1.Korea Univ, Dept Chem, Seoul 02841, South Korea 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Cardiol,Clin Trial Ctr, Wuhan 430071, Peoples R China 5.Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan 430060, Peoples R China 6.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 7.Tibet Univ, Sch Ecol & Environm, Key Lab Biodivers & Environm Qinghai Tibetan Plate, Minist Educ, Lhasa 850000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Jialu,Zhu, Hua,Cai, Huanhuan,et al. De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques[J]. CHEMICAL ENGINEERING JOURNAL,2025,503:13. |
| APA | Gao, Jialu.,Zhu, Hua.,Cai, Huanhuan.,Ding, Qihang.,Xiong, Xiaoxing.,...&Hong, Xuechuan.(2025).De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques.CHEMICAL ENGINEERING JOURNAL,503,13. |
| MLA | Gao, Jialu,et al."De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques".CHEMICAL ENGINEERING JOURNAL 503(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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