GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis
文献类型：期刊论文
| 作者 | Chen, Xi4; Chen, Xin3,4; Yan, Ding4; Zhang, Na4; Fu, Wen4; Wu, Meixuan4; Ge, Feifei4; Wang, Jiangtuan4; Li, Xiaofen4; Geng, Meiyu2
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| 刊名 | NATURE COMMUNICATIONS
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| 出版日期 | 2024-09-27 |
| 卷号 | 15期号:1页码:18 |
| DOI | 10.1038/s41467-024-52398-z |
| 通讯作者 | Wang, Jinheng(wangjh89@gzhmu.edu.cn) ; Tang, Daolin(daolin.tang@utsouthwestern.edu) ; Liu, Jinbao(jliu@gzhmu.edu.cn) |
| 英文摘要 | Despite recent advances, severe acute pancreatitis (SAP) remains a lethal inflammation with limited treatment options. Here, we provide compelling evidence of GV-971 (sodium oligomannate), an anti-Alzheimer's medication, as being a protective agent in various male mouse SAP models. Microbiome sequencing, along with intestinal microbiota transplantation and mass cytometry technology, unveil that GV-971 reshapes the gut microbiota, increasing Faecalibacterium populations and modulating both peripheral and intestinal immune systems. A metabolomics analysis of cecal contents from GV-971-treated SAP mice further identifies short-chain fatty acids, including propionate and butyrate, as key metabolites in inhibiting macrophage M1 polarization and subsequent lethal inflammation by blocking the MAPK pathway. These findings suggest GV-971 as a promising therapeutic for SAP by targeting the microbiota metabolic immune axis. |
| WOS关键词 | INTERNATIONAL SCIENTIFIC ASSOCIATION ; NECROTIZING PANCREATITIS ; CONSENSUS STATEMENT ; PROTEASE ACTIVATION ; MACROPHAGES ; CELLS ; VULNERABILITY ; PROBIOTICS ; PREBIOTICS ; PROTEINS |
| 资助项目 | National Natural Science Foundation of China[82370067] ; Open project of State Key Laboratory of Respiratory Disease[SKLRD-OP-202313] ; Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital[202011-106] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001377401300012 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315175]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Jinheng; Tang, Daolin; Liu, Jinbao |
| 作者单位 | 1.UT Southwestern Med Ctr, Dept Surg, Dallas, TX 75390 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Guangzhou Med Univ, Affiliated Hosp 5, Guangdong Higher Educ Inst, Key Lab Biol Targeting Diag Therapy & Rehabil, Guangzhou 511436, Peoples R China 4.Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou Municipal & Guangdong Prov Key Lab Prot, State Key Lab Resp Dis,Sch Basic Med Sci, Guangzhou 511436, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xi,Chen, Xin,Yan, Ding,et al. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis[J]. NATURE COMMUNICATIONS,2024,15(1):18. |
| APA | Chen, Xi.,Chen, Xin.,Yan, Ding.,Zhang, Na.,Fu, Wen.,...&Liu, Jinbao.(2024).GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis.NATURE COMMUNICATIONS,15(1),18. |
| MLA | Chen, Xi,et al."GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis".NATURE COMMUNICATIONS 15.1(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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