The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels
文献类型：期刊论文
| 作者 | Zheng, Yueyuan1,2; Wen, Qiuyi1,2; Huang, Yushi1,2; Guo, Dean1,2
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| 刊名 | PHARMACEUTICALS
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 17期号:12页码:18 |
| 关键词 | |
| DOI | 10.3390/ph17121735 |
| 通讯作者 | Guo, Dean(daguo@simm.ac.cn) |
| 英文摘要 | Chinese scorpion (CS), a traditional animal-based medicine used for over a millennium, has been documented since AD 935-960. It is derived from the scorpion Buthus martensii Karsch and is used to treat various ailments such as stroke, epilepsy, rheumatism, and more. Modern research has identified the pharmacological mechanisms behind its traditional uses, with active components like venom and proteins showing analgesic, antitumor, antiepileptic, and antithrombotic effects. Studies reveal that CS affects ion channels, crucial for cellular functions, through interactions with sodium, potassium, and calcium channels, potentially explaining its therapeutic effects. Future research aims to elucidate the precise mechanisms, target specific ion channel subtypes, and validate clinical efficacy and safety, paving the way for novel therapies based on these natural compounds. |
| WOS关键词 | BUTHUS-MARTENSII KARSCH ; ANTITUMOR-ANALGESIC PEPTIDE ; CELLS IN-VITRO ; POTASSIUM CHANNELS ; VENOM COMPONENTS ; BMK CT ; TOXIN ; GLIOMA ; EXPRESSION ; IDENTIFICATION |
| 资助项目 | High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province ; [2021B0909050003] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001383928100001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315184]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Dean |
| 作者单位 | 1.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yueyuan,Wen, Qiuyi,Huang, Yushi,et al. The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels[J]. PHARMACEUTICALS,2024,17(12):18. |
| APA | Zheng, Yueyuan,Wen, Qiuyi,Huang, Yushi,&Guo, Dean.(2024).The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels.PHARMACEUTICALS,17(12),18. |
| MLA | Zheng, Yueyuan,et al."The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels".PHARMACEUTICALS 17.12(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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