Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities
文献类型：期刊论文
| 作者 | Ngowi, Ebenezeri Erasto1,2,3; Lu, Tuyan3; Liu, Qing3; Xie, Xianghong3; Wang, Ning3; Luo, Liping3; Deng, Lijuan3; Zhou, Yinghua3; Zhang, Zhihong3; Qiao, Aijun1,2,3 |
| 刊名 | BIOLOGY-BASEL
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 13期号:12页码:18 |
| 关键词 | biofluids exosomes long non-coding RNAs obesity and associated diseases |
| DOI | 10.3390/biology13120976 |
| 通讯作者 | Qiao, Aijun(qiaoaijun@simm.ac.cn) |
| 英文摘要 | Obesity has escalated into a critical global health crisis, tripling in prevalence since the mid-1970s. This increase mirrors the rise in metabolic-associated diseases such as type 2 diabetes (T2D) and its complications, certain cancers, and cardiovascular conditions. While substantial research efforts have enriched our understanding and led to the development of innovative management strategies for these diseases, the suboptimal response rates of existing therapies remain a major obstacle to effectively managing obesity and its associated conditions. Over the years, inter-organ communication (IOC) has emerged as a crucial factor in the development and progression of metabolic disorders. Exosomes, which are nano-sized vesicular couriers released by cells, play a significant role in this communication by transporting proteins, lipids, and nucleic acids across cellular landscapes. The available evidence indicates that exosomal RNAs present in biofluids such as blood, urine, milk, vitreous humor (VH), and cerebrospinal fluid (CSF) are altered in numerous diseases, suggesting their diagnostic and therapeutic potential. Long non-coding RNAs contained in exosomes (exo-lncRNAs) have attracted considerable interest, owing to their ability to interact with critical components involved in a multitude of metabolic pathways. Recent studies have found that alterations in exo-lncRNAs in biofluids correlate with several metabolic parameters in patients with metabolic-associated conditions; however, their exact roles remain largely unclear. This review highlights the diagnostic and therapeutic potential of exosomal lncRNAs in obesity and its associated conditions, emphasizing their role in IOC and disease progression, aiming to pave the way for further research in this promising domain. |
| WOS关键词 | LONG NONCODING RNAS ; BODY-MASS INDEX ; NEUROTROPHIC FACTOR ; GLUCOSE-METABOLISM ; DIABETES-MELLITUS ; CANCER ; SERUM ; BRAIN ; PROTEIN ; ASSOCIATION |
| 资助项目 | National Natural Science Foundation of China ; High-level New R&D Institute of Department of Science and Technology of Guangdong Province[2019B090904008] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Science and Technology Bureau[CXTD2023009] ; [82270925] ; [82470892] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001386728800001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315270]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qiao, Aijun |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ngowi, Ebenezeri Erasto,Lu, Tuyan,Liu, Qing,et al. Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities[J]. BIOLOGY-BASEL,2024,13(12):18. |
| APA | Ngowi, Ebenezeri Erasto.,Lu, Tuyan.,Liu, Qing.,Xie, Xianghong.,Wang, Ning.,...&Qiao, Aijun.(2024).Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities.BIOLOGY-BASEL,13(12),18. |
| MLA | Ngowi, Ebenezeri Erasto,et al."Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities".BIOLOGY-BASEL 13.12(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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