Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL
文献类型：期刊论文
| 作者 | Wan, Jiang2; Zhao, Ze-Yu1,2; Wang, Can2; Jiang, Chun-Xiao1,2; Tong, Ying-Peng2; Zang, Yi4 ; Choo, Yeun-Mun3; Li, Jia4; Hu, Jin-Feng1,2
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 29期号:24页码:18 |
| 关键词 | |
| DOI | 10.3390/molecules29245980 |
| 通讯作者 | Hu, Jin-Feng(jfhu@tzc.edu.cn) |
| 英文摘要 | A comprehensive phytochemical investigation of the twigs/leaves and flower buds of Kolkwitzia amabilis, a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (1-4 and 7-13), 20 triterpenoids (5, 6, and 14-31), and 8 phenylpropanoids (32-39). Among these, amabiliosides A (1) and B (2) represent previously undescribed bis-iridoid glycosides, while amabiliosides C (3) and D (4) feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro-beta-carboline-5-carboxylic acid moiety. Amabiliacids A (5) and B (6) are 24-nor-ursane-type triterpenoids characterized by an uncommon triangle 11,13(18) transannular double bond. Their chemical structures and absolute configurations were elucidated through spectroscopic data and electronic circular dichroism analyses. Compound 2 exhibited a moderate inhibitory effect against acetyl CoA carboxylase 1 (ACC1), with an IC50 value of 9.6 mu M. Lonicejaposide C (8), 3 beta-O-trans-caffeoyl-olean-12-en-28-oic acid (29), and (23E)-coumaroylhederagenin (31) showed notable inhibitory effects on ATP-citrate lyase (ACL), with IC50 values of 3.6, 1.6, and 4.7 mu M, respectively. Additionally, 3 beta-acetyl-ursolic acid (17) demonstrated dual inhibitory activity against both ACC1 and ACL, with IC50 values of 10.3 and 2.0 mu M, respectively. The interactions of the active compounds with ACC1 and ACL enzymes were examined through molecular docking studies. From a chemotaxonomic perspective, the isolation of bis-iridoid glycosides in this study may aid in clarifying the taxonomic relationship between the genera Kolkwitzia and Lonicera within the Caprifoliaceae family. These findings highlight the importance of conserving plant species with unique and diverse secondary metabolites, which could serve as potential sources of new therapeutic agents for treating ACC1/ACL-associated diseases. |
| WOS关键词 | COA CARBOXYLASE INHIBITION ; CYTOTOXIC TRITERPENES ; GLUCOSIDES ; PLANT ; ACID ; CONSTITUENTS ; DERIVATIVES ; SAPONINS |
| 资助项目 | Zhejiang Provincial Natural Science Foundation ; National Science Foundation of China[21937002] ; National Science Foundation of China[82404464] ; [ZCLQ24H3002] ; [LY23H300001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001384907700001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315288]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 2.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Peoples R China 3.Univ Malaya, Fac Sci, Chem Dept, Kuala Lumpur 50603, Malaysia 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Jiang,Zhao, Ze-Yu,Wang, Can,et al. Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL[J]. MOLECULES,2024,29(24):18. |
| APA | Wan, Jiang.,Zhao, Ze-Yu.,Wang, Can.,Jiang, Chun-Xiao.,Tong, Ying-Peng.,...&Hu, Jin-Feng.(2024).Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL.MOLECULES,29(24),18. |
| MLA | Wan, Jiang,et al."Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL".MOLECULES 29.24(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。