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C-X (X=C, O, S, N, B, P) Bond Deuteration and Late-Stage Applications

文献类型：期刊论文

作者Xu, Hui1,2; Zhang, Yun-Qian1,2; Dai, Hui-Xiong1,2,3,4
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2024-10-30
页码17
关键词Late-stage deuteration C-C bond Deuteration C-heteroatom bond deuteration Transition metal catalyst Photocatalyst
ISSN号1434-193X
DOI10.1002/ejoc.202400945
英文摘要Precise deuterium labeling has gained significant attentions owing to the wide applications in organic synthesis, medicinal chemistry, and organic materials. C-C and C-heteroatom bonds constitute the skeleton of organic molecules. This review summarizes the advancements on C-C and C-heteroatom bond deuterations as well as their applications in late-stage deuterations of natural products and pharmaceutically relevant molecules.
WOS关键词CATALYZED REDUCTIVE CLEAVAGE ; HYDROGEN ISOTOPE-EXCHANGE ; H FUNCTIONALIZATION ; CARBOXYLIC-ACIDS ; ARYL KETONES ; CARBON-CYANO ; DEUTERIUM ; DECARBOXYLATION ; ALCOHOLS ; NICKEL
资助项目National Natural Science Foundation of China ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[23ZR1474400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; [22171276] ; [21920102003]
WOS研究方向Chemistry
WOS记录号WOS:001344804100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/314288]  
专题新药研究国家重点实验室
通讯作者Dai, Hui-Xiong
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Hui,Zhang, Yun-Qian,Dai, Hui-Xiong. C-X (X=C, O, S, N, B, P) Bond Deuteration and Late-Stage Applications[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2024:17.
APA Xu, Hui,Zhang, Yun-Qian,&Dai, Hui-Xiong.(2024).C-X (X=C, O, S, N, B, P) Bond Deuteration and Late-Stage Applications.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,17.
MLA Xu, Hui,et al."C-X (X=C, O, S, N, B, P) Bond Deuteration and Late-Stage Applications".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2024):17.

入库方式： OAI收割

来源：上海药物研究所

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