Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders
文献类型：期刊论文
| 作者 | Xie, Zuoquan10 ; Zhou, Qinming9; Hu, Jin1; He, Lu9; Meng, Huangyu9; Liu, Xiaoni6,7,8; Sun, Guangqiang5; Luo, Zhiyu5; Feng, Yuan5; Li, Liang5
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| 刊名 | JOURNAL OF TRANSLATIONAL MEDICINE
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| 出版日期 | 2024-11-01 |
| 卷号 | 22期号:1页码:18 |
| 关键词 | Neuromyelitis optica spectrum disorders Blood immune cells phenotyping Plasma cytokine array Plasma metabolomics Biomarker |
| DOI | 10.1186/s12967-024-05801-8 |
| 英文摘要 | BackgroundNeuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The contribution of peripheral abnormalities to the disease's pathogenesis is not well understood.MethodsTo investigate this, we employed a multi-omics approach analyzing blood samples from 52 NMOSD patients and 46 healthy controls (HC). This included mass cytometry, cytokine arrays, and targeted metabolomics. We then analyzed the peripheral changes of NMOSD, and features related to NMOSD's disease severity. Furthermore, an integrative analysis was conducted to identify the distinguishing characteristics of NMOSD from HC. Additionally, we unveiled the variations in peripheral features among different clinical subgroups within NMOSD. An independent cohort of 40 individuals with NMOSD was utilized to assess the serum levels of fibroblast activation protein alpha (FAP).ResultsOur analysis revealed a distinct peripheral immune and metabolic signature in NMOSD patients. This signature is characterized by an increase in monocytes and a decrease in regulatory T cells, dendritic cells, natural killer cells, and various T cell subsets. Additionally, we found elevated levels of inflammatory cytokines and reduced levels of tissue-repair cytokines. Metabolic changes were also evident, with higher levels of bile acids, lactates, triglycerides, and lower levels of dehydroepiandrosterone sulfate, homoarginine, octadecadienoic acid (FA[18:2]), and sphingolipids. We identified distinctive biomarkers differentiating NMOSD from HC and found blood factors correlating with disease severity. Among these, fibroblast activation protein alpha (FAP) was a notable marker of disease progression.ConclusionsOur comprehensive blood profile analysis offers new insights into NMOSD pathophysiology, revealing significant peripheral immune and metabolic alterations. This work lays the groundwork for future biomarker identification and mechanistic studies in NMOSD, highlighting the potential of FAP as a marker of disease progression. |
| WOS关键词 | FIBROBLAST ACTIVATION PROTEIN ; MULTIPLE-SCLEROSIS ; T-CELLS ; AQUAPORIN-4 ; GALECTIN-2 ; MICROENVIRONMENT ; LYMPHOCYTES ; EXPRESSION ; APOPTOSIS ; DIAGNOSIS |
| 资助项目 | Natural Science Foundation of China for Innovation Research Group |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001345924800001 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314318]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Zuoquan; Zhang, Xiang; Chen, Sheng; Geng, Meiyu |
| 作者单位 | 1.Jiaxing Univ, Dept Neurol, Affiliated Hosp, Jiaxing 314000, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Xinrui Hosp, Dept Neurol, Wuxi, Peoples R China 4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China 5.Shanghai Green Valley Pharmaceut Co Ltd, Shanghai 201203, Peoples R China 6.Natl Ctr Neurol Disorders, Shanghai 200040, Peoples R China 7.Fudan Univ, Inst Neurol, Shanghai, Peoples R China 8.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China 9.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China 10.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zuoquan,Zhou, Qinming,Hu, Jin,et al. Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2024,22(1):18. |
| APA | Xie, Zuoquan.,Zhou, Qinming.,Hu, Jin.,He, Lu.,Meng, Huangyu.,...&Geng, Meiyu.(2024).Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders.JOURNAL OF TRANSLATIONAL MEDICINE,22(1),18. |
| MLA | Xie, Zuoquan,et al."Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders".JOURNAL OF TRANSLATIONAL MEDICINE 22.1(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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