Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment
文献类型：期刊论文
| 作者 | Wang, Yue3,4; Ding, Qihang7; Ma, Gongcheng4; Zhang, Zhiwei4; Wang, Jiaqi3; Lu, Chang3; Xiang, Chunbai4; Qian, Kun5; Zheng, Jun3; Shan, Yaming6 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 18期号:45页码:31349-31359 |
| 关键词 | bacterial pneumonia antibacterial treatments mucus layer biomimetic natural killer cells |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.4c10837 |
| 英文摘要 | Bacterial pneumonia has garnered significant attention in the realm of infectious diseases owing to a surge in the incidence of severe infections coupled with the growing scarcity of efficacious therapeutic modalities. Antibiotic treatment is still an irreplaceable method for bacterial pneumonia because of its strong bactericidal activity and good clinical efficacy. However, the mucus layer forming after a bacterial infection in the lungs has been considered as the "Achilles' heels" facing the clinical application of such treatment. Herein, traceable biomimetic nanoantibiotics (BioNanoCFPs) were developed by loading indacenodithieno[3,2-b]thiophene (ITIC) and cefoperazone (CFP) in nanoplatforms coated with natural killer (NK) cell membranes. The BioNanoCFP exhibited excellent demonstrated mucus-penetrating abilities, facilitating their arrival at the infection site. The presence of Toll-like receptors in the NK cell membrane rendered the BioNanoCFP with the capability to recognize pathogen-associated molecular patterns within bacteria, allowing precise targeting of bacterial colonization sites and achieving substantial therapeutic efficacy. Overall, our findings demonstrate the viability and desirability of using NK cell membrane-mediated drug delivery as a promising strategy for precision treatment. |
| WOS关键词 | IMMUNE ; RECOGNITION ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China[2019YFA0904400] ; National Key R&D Program of China[2023A1515010549] ; Natural Science Foundation of Guangdong Province[FDCT/0009/2023/RIC] ; Natural Science Foundation of Guangdong Province[FDCT/0043/2021/A1] ; Science and Technology Development Fund of Macau[MYRG2022-00143-FHS] ; Science and Technology Development Fund of Macau[MYRG-GRG2023-00158-FHS-UMDF] ; University of Macau[JCYJ20210324120011030] ; Shenzhen Basic Research (key project) (China)[KQTD20210811090115019] ; Shenzhen Science and Technology Program[ZDKYYQ20220008] ; Major Instrumentation Development Program of the Chinese Academy of Sciences[2021YFA0910000] ; Major Instrumentation Development Program of the Chinese Academy of Sciences[2023YFA0915400] ; National Key Research and Development Program of China[U2267221] ; National Natural Science Foundation of China[SYS202205] ; Shandong Laboratory Program[SIMM0120231004] ; State Key Laboratory of Drug Research[23ZDFA014] ; Gansu Science and Technology Major Project[2414050002188] ; Guangdong Provincial Natural Science Foundation ; Shenzhen Science[JCYJ20210324115804013] ; Shenzhen Science[JCYJ20220818101607016] ; Technology Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS记录号 | WOS:001348345300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314345]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Qihang; Zhang, Pengfei; Cheng, Zhen; Gong, Ping; Zhao, Qi |
| 作者单位 | 1.Sino Euro Ctr Biomed & Hlth, Shenzhen 518024, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Univ Macau, Inst Translat Med, Fac Hlth Sci, Canc Ctr, Taipa 999078, Macau, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, CAS Key Lab Biomed Imaging Sci & Syst, Guangdong Key Lab Nanomed,CAS HK Joint Lab Biomat,, Shenzhen 518055, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130012, Jilin, Peoples R China 7.Korea Univ, Dept Chem, Seoul 02841, South Korea |
| 推荐引用方式 GB/T 7714 | Wang, Yue,Ding, Qihang,Ma, Gongcheng,et al. Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment[J]. ACS NANO,2024,18(45):31349-31359. |
| APA | Wang, Yue.,Ding, Qihang.,Ma, Gongcheng.,Zhang, Zhiwei.,Wang, Jiaqi.,...&Zhao, Qi.(2024).Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment.ACS NANO,18(45),31349-31359. |
| MLA | Wang, Yue,et al."Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment".ACS NANO 18.45(2024):31349-31359. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。