Thiocyanoalkylation of alkenes via dual photoredox and copper catalysis
文献类型：期刊论文
| 作者 | Wang, Xu1,2,3; Xiao, Bi-Yin1,2; Jiang, Qi-Xuan1,2; Huang, Wei1,2,3; Zhang, Feng-Hua1,2 |
| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2024-11-07 |
| 页码 | 6 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d4qo01864h |
| 英文摘要 | Organic thiocyanates are commonly used as essential organic synthesis intermediates and are widely present in various drug molecules and bioactive molecules. Herein, a copper- and photoredox-catalyzed thiocyanoalkylation reaction of terminal alkenes with NHPI esters and NH4SCN to access organic thiocyanates is described. This protocol employs the more readily accessible NHPI ester as a radical precursor under redox-neutral conditions. Moreover, the reaction exhibits high compatibility with diverse primary, secondary and tertiary NHPI esters. The late-stage modification of some drugs and structurally complex natural products enables the potential application in organic synthesis. |
| WOS关键词 | DIFUNCTIONALIZATION ; GENERATION ; ACCESS |
| 资助项目 | Natural Science Foundation of Zhejiang Province[LQ24B020006] ; Zhejiang Provincial Natural Science Foundation of China[TD2020005] ; Hangzhou Innovation and Entrepreneurship Leading Team Project[2023YFD1800100] ; National Key Research and Development Program of China |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001353080900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314394]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Feng-Hua |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xu,Xiao, Bi-Yin,Jiang, Qi-Xuan,et al. Thiocyanoalkylation of alkenes via dual photoredox and copper catalysis[J]. ORGANIC CHEMISTRY FRONTIERS,2024:6. |
| APA | Wang, Xu,Xiao, Bi-Yin,Jiang, Qi-Xuan,Huang, Wei,&Zhang, Feng-Hua.(2024).Thiocyanoalkylation of alkenes via dual photoredox and copper catalysis.ORGANIC CHEMISTRY FRONTIERS,6. |
| MLA | Wang, Xu,et al."Thiocyanoalkylation of alkenes via dual photoredox and copper catalysis".ORGANIC CHEMISTRY FRONTIERS (2024):6. |
入库方式： OAI收割
来源：上海药物研究所
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