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Alveolar regeneration by airway secretory-cell-derived p63+progenitors

文献类型：期刊论文

作者Lv, Zan2; Liu, Zixin2; Liu, Kuo1; Lin, Xiuyu2; Pu, Wenjuan2; Li, Yan3,7; Zhao, Huan2; Xi, Ying5; Sui, Pengfei2; Vaughan, Andrew E.4
刊名CELL STEM CELL
出版日期2024-11-07
卷号31期号:11页码:23
ISSN号1934-5909
DOI10.1016/j.stem.2024.08.005
英文摘要Lung injury activates epithelial stem or progenitor cells for alveolar repair and regeneration. Unraveling the origin and fate of injury-induced progenitors is crucial for elucidating lung repair mechanisms. Here, we report that p63-expressing progenitors emerge upon bleomycin-induced mouse lung injury. Single-cell RNA sequencing and clonal analysis reveal that these p63+ progenitors proliferate rapidly and differentiate into alveolar type 1 and type 2 cells through different trajectories. Dual recombinase-mediated sequential genetic-lineage tracing demonstrates that p63+ progenitors originate from airway secretory cells and subsequently generate alveolar cells. Functionally, p63 activation is essential for efficient alveolar regeneration from secretory cells post injury. Our study identifies secretory-cell-derived p63+ progenitors as contributors to alveolar repair, suggesting a potential therapeutic avenue for lung regeneration following injury.
WOS关键词STEM-CELLS ; PULMONARY-FIBROSIS ; EPITHELIAL-CELLS ; PROGENITOR CELLS ; LUNG REPAIR ; P63 ; LINEAGE ; PROLIFERATION ; MAINTENANCE ; POPULATION
资助项目National Key Research & Development Program of China[2023YFA1800700] ; National Key Research & Development Program of China[2022YFA1104200] ; National Key Research & Development Program of China[2023YFA1801300] ; National Science Foundation of China[82088101] ; National Science Foundation of China[32370897] ; National Science Foundation of China[32370783] ; National Science Foundation of China[32370802] ; National Science Foundation of China[32100592] ; National Science Foundation of China[32170848] ; National Science Foundation of China[32100585] ; National Science Foundation of China[32100648] ; Strategic Priority Research Program of CAS ; CAS Project for Young Scientists in Basic Research[YSBR-012] ; Youth Innovation Promotion Association CAS ; Shanghai Pilot Program for Basic Research - CAS, Shanghai Branch[JCYJ-SHFY-2021-0] ; Shanghai Municipal Science and Technology Major Project, Chinese Postdoctoral Science Foundation ; XPLORER PRIZE ; New Cornerstone Science Foundation
WOS研究方向Cell Biology
WOS记录号WOS:001354000200001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/314397]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin
作者单位1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China
2.Chinese Acad Sci, New Cornerstone Sci Lab, Key Lab Multicell Syst, Shanghai Inst Biochem & Cell Biol,Ctr Excellence M, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Univ Penn, Sch Vet Med, Dept Biomed Sci, Philadelphia, PA 19104 USA
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
6.Calico Life Sci LLC, South San Francisco, CA 94080 USA
7.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Zan,Liu, Zixin,Liu, Kuo,et al. Alveolar regeneration by airway secretory-cell-derived p63+progenitors[J]. CELL STEM CELL,2024,31(11):23.
APA Lv, Zan.,Liu, Zixin.,Liu, Kuo.,Lin, Xiuyu.,Pu, Wenjuan.,...&Zhou, Bin.(2024).Alveolar regeneration by airway secretory-cell-derived p63+progenitors.CELL STEM CELL,31(11),23.
MLA Lv, Zan,et al."Alveolar regeneration by airway secretory-cell-derived p63+progenitors".CELL STEM CELL 31.11(2024):23.

入库方式： OAI收割

来源：上海药物研究所

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