Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer
文献类型：期刊论文
| 作者 | Wang, Bei5,6; Wang, Zixuan1,4; Wang, Kun3; Shao, Zhongming5; Chen, Haitao5; Xu, Lincheng5; Pan, Yan5; Zheng, Mingyue2,3,6 ; Geng, Wei5; Xu, Chuanhai5
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| 刊名 | FUTURE ONCOLOGY
 |
| 出版日期 | 2024-11-12 |
| 页码 | 12 |
| 关键词 | esophageal squamous cell carcinoma immunotherapy inflammatory markers prognosis tumor infiltrating lymphocytes |
| ISSN号 | 1479-6694 |
| DOI | 10.1080/14796694.2024.2421151 |
| 英文摘要 | Aim: To investigate the prognostic value of inflammatory markers in esophageal squamous cell carcinoma (ESCC) patients treated with immune checkpoint inhibitors (ICIs).Materials & methods: The infiltration of CD3+ and CD8+ T cells in tissue microarrays from 180 patients who underwent radical esophagectomy was detected using immunohistochemistry. A separate cohort of 351 patients with metastatic/recurrent or unresectable ESCC treated with ICIs was enrolled for further investigation. The overall survival difference among groups was assessed using Kaplan-Meier analysis. Cox proportional hazards models were employed to investigate the prognostic impact of the inflammatory markers, along with other factors.Results: Decreased inflammation was found to be associated with increased CD3+ and CD8+ T-cell infiltration and a better prognosis. Then, the value of inflammatory markers in predicting survival in 351 ESCC patients receiving immunotherapy was validated. Ultimately, the systemic immune-inflammation index was identified as an independent prognostic factor for overall survival. Additionally, the patients with no distant organ metastasis, or treated by first-line immunotherapy combined with concurrent chemoradiotherapy can considerably prolong survival.Conclusion: Inflammation is associated with the level of tumor infiltrating lymphocytes and that the systemic immune-inflammation index is an effective prognostic predictor for ESCC patients treated with ICIs. |
| WOS关键词 | PEMBROLIZUMAB ; METASTASIS ; CELLS ; INDEX |
| 资助项目 | Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program[YB2020079] ; Project of National Clinical Research Base of Traditional Chinese Medicine in Jiangsu Province, China[JD2023SZX14] ; Project of Jiangsu Health Commission[Z2022016] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:001353195000001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314400]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Geng, Wei; Xu, Chuanhai |
| 作者单位 | 1.Xuzhou Med Univ, Grad Sch, 209 Tongshan Rd, Xuzhou 221004, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230026, Peoples R China 4.Jiangsu Canc Hosp, Jiangsu Inst Canc Res, 42 Baizi Pavil, Nanjing 210009, Peoples R China 5.Xuzhou Med Univ, Peoples Hosp Yancheng 1, Yancheng Clin Coll, 66 South Peoples Rd, Yancheng 224000, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Bei,Wang, Zixuan,Wang, Kun,et al. Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer[J]. FUTURE ONCOLOGY,2024:12. |
| APA | Wang, Bei.,Wang, Zixuan.,Wang, Kun.,Shao, Zhongming.,Chen, Haitao.,...&Xu, Chuanhai.(2024).Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer.FUTURE ONCOLOGY,12. |
| MLA | Wang, Bei,et al."Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer".FUTURE ONCOLOGY (2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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