Integrated computational approaches for advancing antimicrobial peptide development
文献类型：期刊论文
| 作者 | Fang, Yanpeng1,4; Ma, Yeshuo2,4; Yu, Kunqian3 ; Dong, Jie1,4; Zeng, Wenbin1,4
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| 刊名 | TRENDS IN PHARMACOLOGICAL SCIENCES
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 45期号:11页码:15 |
| ISSN号 | 0165-6147 |
| DOI | 10.1016/j.tips.2024.09.011 |
| 英文摘要 | The increasing prevalence of antimicrobial resistance has intensified the need for novel antimicrobial drugs. Antimicrobial peptides (AMPs) are promising alternative antibiotics due to their broad-spectrum activity and slower resistance development. However, the time-consuming, costly development and challenge of systematic optimization limit their translation into the clinic. Recently, integrating computational methods have led to breakthroughs in the precise design and optimization of AMPs, reduced resource consumption, and accelerated AMP development process. We highlight the application of these integrated approaches in AMP molecule discovery, optimization, and delivery and demonstrate the synergy of these strategies to fuel AMP development. |
| WOS关键词 | DATABASE ; BINDING ; TOOLS |
| 资助项目 | National Natural Science Foundation of China[82272067] ; National Natural Science Foundation of China[82273486] ; National Natural Science Foundation of China[M-0696] ; National Key R&D Program of China[2023YFC2604404] ; Science and Technology Innovation Program of Hunan Province[2024RC3004] ; Science and Technology Foundation of Hunan Province[2022JJ80052] ; Central South University Innovation-Driven Research Program[2023CXOD004] ; Health Commission of Hunan Province Project[D202303017033] ; Innovation Fund for Postgraduate Students of Central South University[2022ZZTS0226] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001354713900001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314418]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dong, Jie; Zeng, Wenbin |
| 作者单位 | 1.Hunan Key Lab Diagnost & Therapeut Drug Res Chron, Changsha 410078, Peoples R China 2.Cent South Univ, Xiangya Hosp 3, Changsha 410083, Peoples R China 3.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Yanpeng,Ma, Yeshuo,Yu, Kunqian,et al. Integrated computational approaches for advancing antimicrobial peptide development[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2024,45(11):15. |
| APA | Fang, Yanpeng,Ma, Yeshuo,Yu, Kunqian,Dong, Jie,&Zeng, Wenbin.(2024).Integrated computational approaches for advancing antimicrobial peptide development.TRENDS IN PHARMACOLOGICAL SCIENCES,45(11),15. |
| MLA | Fang, Yanpeng,et al."Integrated computational approaches for advancing antimicrobial peptide development".TRENDS IN PHARMACOLOGICAL SCIENCES 45.11(2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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