Ruthenium(II)-Catalyzed Pyridyl-Directed Tryptophan C-H Acylmethylation with α-Chloro Ketones
文献类型：期刊论文
| 作者 | Hu, Shulei3,4; Wang, Yong4; Xie, Xiong4; Liang, Renwen4; Liu, Hong1,3,4 ; Wang, Jiang2,4
|
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2024-11-18 |
| 页码 | 7 |
| 关键词 | C-H functionalization
Ru(II)-catalyzed
Acylmethylation
|
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.202400947 |
| 英文摘要 | A ruthenium(II)-catalyzed C-H acylmethylation of Trp-containing peptides with alpha-chloro ketones is reported here. This reaction features good C-2 selectivity and chemoselectivity, making it suitable for late-stage modification of Trp-containing peptides. Low-cost metal ruthenium as a catalyst enables the reaction to be conducted on a gram scale. This report also discusses the synthetic applications and presents a method to remove the pyridine directing group. In addition, a plausible mechanism of the C(2)-H acylmethylation reaction is proposed in this article. |
| WOS关键词 | C(SP(3))-H ARYLATION ; AMINO-ACIDS ; PEPTIDES ; MILD |
| 资助项目 | China[2022YFA1302900] ; National Key R&D Program of China[82130105] ; National Key R&D Program of China[22337003] ; National Key R&D Program of China[82121005] ; National Key R&D Program of China[82322063] ; National Key R&D Program of China[22177124] ; National Key R&D Program of China[LG-GG-202403-01] ; National Natural Science Foundation of China[23XD1460300] ; Program of Shanghai Academic Research Leader |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001356860500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314506]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Wang, Jiang |
| 作者单位 | 1.Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Peoples R China 2.Lingang Lab, Shanghai 200031, Peoples R China 3.China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Shulei,Wang, Yong,Xie, Xiong,et al. Ruthenium(II)-Catalyzed Pyridyl-Directed Tryptophan C-H Acylmethylation with α-Chloro Ketones[J]. ADVANCED SYNTHESIS & CATALYSIS,2024:7. |
| APA | Hu, Shulei,Wang, Yong,Xie, Xiong,Liang, Renwen,Liu, Hong,&Wang, Jiang.(2024).Ruthenium(II)-Catalyzed Pyridyl-Directed Tryptophan C-H Acylmethylation with α-Chloro Ketones.ADVANCED SYNTHESIS & CATALYSIS,7. |
| MLA | Hu, Shulei,et al."Ruthenium(II)-Catalyzed Pyridyl-Directed Tryptophan C-H Acylmethylation with α-Chloro Ketones".ADVANCED SYNTHESIS & CATALYSIS (2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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