Near-Infrared Activatable Copper Nanoplatforms Synergize with the 5-Azacytidine Prodrug to Potentiate Cuproptosis
文献类型：期刊论文
| 作者 | Wang, Shuo3; Liu, Yishen1,4,5,6; Su, Mengya1,4,5,6; Wang, Yuanyuan3; Wang, Wenda3; Wang, Wuyin3; Yang, Qichao3; Zhang, Zhiyun1,2,5,6; Hong, Xuechuan1,2,4,5,6; Sun, Zhijun3 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2024-11-09 |
| 页码 | 13 |
| 关键词 | cuproptosis near-infrared light photocatalysis antitumor therapy ferredoxin 1 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202411609 |
| 英文摘要 | Cuproptosis, a newly discovered cell death modality, is gaining recognition for its crucial role in antitumor therapy. Here, we demonstrated that Ferredoxin 1 (FDX1), a key gene involved in cuproptosis, is negatively correlated with malignancy and T-cell exhaustion in head and neck squamous cell carcinoma (HNSCC). Based on these findings, we developed near-infrared (NIR) light-controlled nanoparticles (NPs), CuD@PM, which can selectively deliver copper to HNSCC cells and induce cuproptosis in the presence of microneedles loaded with triacetylated azacitidine (TAc-AzaC) and 808 nm laser irradiation. Intravenous administration of these NPs significantly suppressed tumor growth in HNSCC animal models and enhanced the antitumor immune response. The NIR-controlled activation of cuproptosis offers great potential as a safe, targeted, and image-guided antitumor therapy for HNSCC. |
| WOS关键词 | NECK-CANCER ; HEAD |
| 资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China[22477129] ; National Natural Science Foundation of China[82472818] ; National Natural Science Foundation of China[82273202] ; National Natural Science Foundation of China[82273796] ; Interdisciplinary Innovative Foundation of Wuhan University[XNJC202303] ; Innovation Team of Wuhan University[2042017kf0232] ; Shandong Laboratory Program[SYS202205] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Shenzhen Science and Technology Research Grant[JCYJ20230807090100002] ; Shenzhen Science and Technology Research Grant[JCYJ20220530140605012] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Science and Technology Planning Project of Lhasa[LSKJ202445] ; Fundamental Research Funds for the Central Universities[2042022dx0003] ; [2023YFC3605502] ; [2022YFC2504200] |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001357607000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314515]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Sun, Zhijun; Xiao, Yuling |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 430060, Peoples R China 2.Wuhan Univ, State Key Lab Virol & Biosafety CAS, Shenzhen Inst, Shenzhen 518057, Peoples R China 3.Wuhan Univ, Sch & Hosp Stomatol, Frontier Sci Ctr Immunol & Metab, Taikang Ctr Life & Med Sci,State Key Lab Oral & Ma, Wuhan 430079, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Cardiol, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shuo,Liu, Yishen,Su, Mengya,et al. Near-Infrared Activatable Copper Nanoplatforms Synergize with the 5-Azacytidine Prodrug to Potentiate Cuproptosis[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2024:13. |
| APA | Wang, Shuo.,Liu, Yishen.,Su, Mengya.,Wang, Yuanyuan.,Wang, Wenda.,...&Xiao, Yuling.(2024).Near-Infrared Activatable Copper Nanoplatforms Synergize with the 5-Azacytidine Prodrug to Potentiate Cuproptosis.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,13. |
| MLA | Wang, Shuo,et al."Near-Infrared Activatable Copper Nanoplatforms Synergize with the 5-Azacytidine Prodrug to Potentiate Cuproptosis".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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