Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
文献类型：期刊论文
| 作者 | Liu, Yadan1,2; Ye, Jialin3,4; Fan, Zisheng5,6; Wu, Xiaolong1,7; Zhang, Yinghui1,4; Yang, Ruirui1,4; Jiang, Bing1,2; Wang, Yajie1,8; Wu, Min1; Zhou, Jingyi1 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2024-11-19 |
| 页码 | 15 |
| 关键词 | cGAS-STING signaling Ginkgetin senescence STING inhibitor target identification |
| DOI | 10.1002/advs.202407222 |
| 英文摘要 | Ginkgo biloba extract is reported to have therapeutic effects on aging-related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient of Ginkgo biloba extract, can alleviate cellular senescence and improve pathologies in multiple tissues of aging mice. To reveal the molecular mechanism of Ginkgetin's anti-aging effect, a graph convolutional network-based drug "on-target" pathway prediction algorithm for prediction is employed. The results indicate that the cGAS-STING pathway may be a potential target for Ginkgetin. Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy-terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. Furthermore, in vivo pharmacodynamic data showed that Ginkgetin effectively alleviates systemic inflammation in Trex1-/- mice and inhibits the abnormally activated STING signaling in aging mouse model. In summary, this study, utilizing an artificial intelligence algorithm combined with pharmacological methods, confirms STING serves as a critical target for Ginkgetin in alleviating inflammation and senescence. Importantly, this study elucidates the specific component and molecular mechanism underlying the anti-aging effect of Ginkgo biloba extract, providing a robust theoretical basis for its therapeutic use. |
| WOS关键词 | CELLULAR SENESCENCE ; SECRETORY PHENOTYPE ; OXIDATIVE STRESS ; BILOBA EXTRACT ; BIFLAVONOIDS ; CELLS ; CHROMATIN ; DISEASE ; LEAVES ; DNA |
| 资助项目 | National Natural Science Foundation of China[T2225002] ; National Natural Science Foundation of China[82273855] ; National Natural Science Foundation of China[81903639] ; National Natural Science Foundation of China[82304379] ; National Key Research and Development Program of China[2023YFC2305904] ; National Key Research and Development Program of China[2022YFC3400504] ; Youth Innovation Promotion Association CAS[2023296] ; Open fund of state key laboratory of Pharmaceutical Biotechnology, Nanjing University, China[KF-202301] ; SIMM-SHUTCM Traditional Chinese Medicine Innovation Joint Research Program[E2G805H] ; Natural Science Foundation of Shanghai[22ZR1474300] ; Young Elite Scientists Sponsorship Program by CAST[2023QNRC001] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001357868600001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314521]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiao, Yichuan; Zheng, Mingyue; Zhang, Sulin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Lingang Lab, Shanghai 200031, Peoples R China 7.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 8.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmacol Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yadan,Ye, Jialin,Fan, Zisheng,et al. Ginkgetin Alleviates Inflammation and Senescence by Targeting STING[J]. ADVANCED SCIENCE,2024:15. |
| APA | Liu, Yadan.,Ye, Jialin.,Fan, Zisheng.,Wu, Xiaolong.,Zhang, Yinghui.,...&Zhang, Sulin.(2024).Ginkgetin Alleviates Inflammation and Senescence by Targeting STING.ADVANCED SCIENCE,15. |
| MLA | Liu, Yadan,et al."Ginkgetin Alleviates Inflammation and Senescence by Targeting STING".ADVANCED SCIENCE (2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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