Substrate and Functional Diversity of Protein Lysine Post-translational Modifications
文献类型：期刊论文
| 作者 | Hao, Bingbing1,6,7; Chen, Kaifeng6,7; Zhai, Linhui2,3,6; Liu, Muyin4; Liu, Bin5; Tan, Minjia2,6,7
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| 刊名 | GENOMICS PROTEOMICS & BIOINFORMATICS
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| 出版日期 | 2024-02-28 |
| 卷号 | 22期号:1页码:21 |
| 关键词 | Protein lysine PTM Regulatory enzyme PTM crosstalk Drug target Acylation |
| ISSN号 | 1672-0229 |
| DOI | 10.1093/gpbjnl/qzae019 |
| 英文摘要 | Lysine post-translational modifications (PTMs) are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone proteins. Dysregulation of lysine PTMs is implicated in many diseases, and targeting lysine PTM regulatory factors, including writers, erasers, and readers, has become an effective strategy for disease therapy. The continuing development of mass spectrometry (MS) technologies coupled with antibody-based affinity enrichment technologies greatly pro-motes the discovery and decoding of PTMs. The global characterization of lysine PTMs is crucial for deciphering the regulatory networks, mo-lecular functions, and mechanisms of action of lysine PTMs. In this review, we focus on lysine PTMs, and provide a summary of the regulatory enzymes of diverse lysine PTMs and the proteomics advances in lysine PTMs by MS technologies. We also discuss the types and bi-ological functions of lysine PTM crosstalks on histone and non-histone proteins and current druggable targets of lysine PTM regulatory factors for disease therapy. |
| WOS关键词 | MASS-SPECTROMETRY ANALYSIS ; E3 UBIQUITIN LIGASE ; HISTONE CROTONYLATION ; GENE-EXPRESSION ; METABOLIC-REGULATION ; PROTEOMIC ANALYSIS ; GLOBAL IDENTIFICATION ; MEDIATED DEGRADATION ; ACETYLATION ; METHYLATION |
| 资助项目 | Program of Shanghai Academic Research Leader[22XD1420900] ; National Natural Science Foundation of China[22225702] ; National Natural Science Foundation of China[32071432] ; National Natural Science Foundation of China[32171434] ; National Natural Science Foundation of China[81821005] ; Youth Science and Technology Talents in Shanghai Sail Plan of China[21YF1456000] ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China[KF-202201] ; Guangdong High-level New R&D Institute, China[2019B090904008] ; Guangdong High-level Innovative Research Institute, China[2021B0909050003] |
| WOS研究方向 | Genetics & Heredity |
| WOS记录号 | WOS:001356823500001 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314533]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tan, Minjia |
| 作者单位 | 1.Zhengzhou Univ, Inst Adv Biomed Sci, Tianjian Lab Adv Biomed Sci, Zhengzhou 450001, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China 5.Jiangsu Ocean Univ, Coll Pharm, Jiangsu Key Lab Marine Pharmaceut Cpd Screening, Lianyungang 222005, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Bingbing,Chen, Kaifeng,Zhai, Linhui,et al. Substrate and Functional Diversity of Protein Lysine Post-translational Modifications[J]. GENOMICS PROTEOMICS & BIOINFORMATICS,2024,22(1):21. |
| APA | Hao, Bingbing,Chen, Kaifeng,Zhai, Linhui,Liu, Muyin,Liu, Bin,&Tan, Minjia.(2024).Substrate and Functional Diversity of Protein Lysine Post-translational Modifications.GENOMICS PROTEOMICS & BIOINFORMATICS,22(1),21. |
| MLA | Hao, Bingbing,et al."Substrate and Functional Diversity of Protein Lysine Post-translational Modifications".GENOMICS PROTEOMICS & BIOINFORMATICS 22.1(2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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