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Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles

文献类型：期刊论文

作者Wu, Huaping2,3,4; Tang, Lin2,3,4; Dong, Huanhuan1; Zhi, Maoxin1; Guo, Liqiong1; Hong, Xuechuan2,3,4; Liu, Mingzhe1; Xiao, Yuling2,3,4; Zeng, Xiaodong2,3,4
刊名MOLECULAR PHARMACEUTICS
出版日期2024-11-26
页码13
关键词gold nanoparticles nanoparticle morphology toxicity assessment biodistribution pharmacokinetics
ISSN号1543-8384
DOI10.1021/acs.molpharmaceut.4c00832
英文摘要Gold nanoparticles (AuNPs) are extensively utilized in biomolecular sensing, photothermal therapy, drug delivery, and various imaging techniques like photoacoustic and fluorescent imaging. Despite their diverse applications, inconsistent findings from previous toxicity studies underscore the critical need for standardized methodologies. This study introduces ten distinct types of AuNPs-cubes, stars, rods, dumbbells, and bipyramids at sizes of 50 and 100 nm, to systematically assess their toxicity under controlled conditions both in vitro and in vivo. Our findings reveal a clear correlation between cytotoxicity and the morphology, size, incubation duration, and concentration of AuNPs. Anisotropically shaped nanoparticles, such as nanorods, nanodumbbells, and nanobipyramids, tend to exhibit higher cytotoxicity compared to more spherical forms like nanocubes and nanostars. Interestingly, while in vivo plasma biochemistry parameters show minimal variation, biodistribution, histopathological alterations, and pharmacokinetics are notably influenced by the shape and size of AuNPs. In most instances, smaller and anisotropic AuNPs that remain in the bloodstream for extended periods are observed. This research offers significant insights into the design of AuNPs with specific morphologies and sizes, particularly for their application in drug delivery systems via intravenous injection. These outcomes emphasize the nuanced toxicity profiles of AuNPs, necessitating tailored approaches in preclinical and clinical research.
WOS关键词IN-VIVO TOXICITY ; NANORODS ; DELIVERY ; GROWTH ; VITRO
资助项目National Natural Science Foundation of China[2020YFA0908800] ; National Key R&D Program of China[21204069] ; National Natural Science Foundation of China[SYS202205] ; Shandong Laboratory Program[ZR2023MB085] ; Natural Science Foundation of Shandong Province[tsqn202306320] ; Taishan Scholar Project
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:001363778800001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/314783]  
专题新药研究国家重点实验室
通讯作者Liu, Mingzhe; Xiao, Yuling; Zeng, Xiaodong
作者单位1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Dept Organ Chem, Shenyang 110016, Liaoning, Peoples R China
2.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Cardiol,Clin Trial Ctr, Wuhan 430071, Peoples R China
3.Shandong Lab Yantai Drug Discovery, Bohai Rim Adv Res Inst Drug Discovery, Yantai 264117, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Huaping,Tang, Lin,Dong, Huanhuan,et al. Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles[J]. MOLECULAR PHARMACEUTICS,2024:13.
APA Wu, Huaping.,Tang, Lin.,Dong, Huanhuan.,Zhi, Maoxin.,Guo, Liqiong.,...&Zeng, Xiaodong.(2024).Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles.MOLECULAR PHARMACEUTICS,13.
MLA Wu, Huaping,et al."Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles".MOLECULAR PHARMACEUTICS (2024):13.

入库方式： OAI收割

来源：上海药物研究所

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