A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights
文献类型：期刊论文
| 作者 | Yu, Jing14,15; Gui, Xiuqi13; Zou, Yunhao11,12; Liu, Qian10; Yang, Zhicheng10,11; An, Jusheng15; Guo, Xuan11,13; Wang, Kaihua11,12; Guo, Jiaming10,11; Huang, Manni15 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2024-11-22 |
| 卷号 | 15期号:1页码:23 |
| DOI | 10.1038/s41467-024-53830-0 |
| 英文摘要 | Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women's health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes. EP300 is found to enhance the acetylation of FOSL2-K222, consequently accelerating the malignant proliferation of CC cells. Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. This study provides a valuable public resource for researchers and clinicians to delve into the molecular basis of CC, to identify potential treatments and to ultimately advance clinical practice. Cervical cancer remains a significant public health problem in many regions. Here, the authors perform a proteogenomic analysis of cervical cancer in Chinese patients; they reveal proteomic subgroups associated with clinical and biological features, and a potential biomarker of response to radiotherapy. |
| WOS关键词 | KINASE-C BETA ; PAPILLOMAVIRUS SEQUENCES ; RADIATION-THERAPY ; P300 ; CARCINOMA ; ADENOCARCINOMA ; HETEROGENEITY ; REGULATORS ; INHIBITOR ; LANDSCAPE |
| 资助项目 | National Natural Science Foundation of China (National Science Foundation of China)[2022YFA1302900] ; National Natural Science Foundation of China (National Science Foundation of China)[2020YFA0803203] ; National Natural Science Foundation of China (National Science Foundation of China)[2019YFA0802102] ; National Key Research and Development Program of China[20XD1424900] ; Shanghai Young Excellent Academic Leader Program[82173334] ; Shanghai Young Excellent Academic Leader Program[32370705] ; Shanghai Young Excellent Academic Leader Program[81925029] ; Shanghai Young Excellent Academic Leader Program[82230098] ; Shanghai Young Excellent Academic Leader Program[32221002] ; Shanghai Young Excellent Academic Leader Program[22425703] ; National Natural Science Foundation of China[XDB0850000] ; National Natural Science Foundation of China[XDB38040100] ; Strategic Priority Research Program of Chinese Academy of Sciences[YSBR-014] ; CAS Project for Young Scientists in Basic Research ; Shanghai Municipal Science and Technology Major Projects ; Institutional Technology Service Center of Shanghai Institute of Materia Medica ; US National Cancer Institute's International Cancer Proteogenome Consortium |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001362461900017 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314786]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Hu; Shao, Zhen; Wu, Lingying; Gao, Daming |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China 3.NCI, Off Canc Clin Proteom Res, Rockville, MD 20850 USA 4.Washington Univ, Siteman Canc Ctr, Sch Med, St Louis, MO 63108 USA 5.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Dept Mol & Human Genet, One Baylor Pl, Houston, TX USA 6.Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA 7.Yale Univ, Canc Biol Inst, Sch Med, Dept Pharmacol, West Haven, CT USA 8.Bruker Beijing Sci Technol Co, Ltd, Shanghai, Peoples R China 9.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Natl Canc Ctr,Dept Pathol, Beijing, Peoples R China 10.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Res Ctr Organ & Biol Mol, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jing,Gui, Xiuqi,Zou, Yunhao,et al. A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights[J]. NATURE COMMUNICATIONS,2024,15(1):23. |
| APA | Yu, Jing.,Gui, Xiuqi.,Zou, Yunhao.,Liu, Qian.,Yang, Zhicheng.,...&Gao, Daming.(2024).A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights.NATURE COMMUNICATIONS,15(1),23. |
| MLA | Yu, Jing,et al."A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights".NATURE COMMUNICATIONS 15.1(2024):23. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。