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An overview of the functions and mechanisms of APOBEC3A in tumorigenesis

文献类型：期刊论文

作者Yang, Yuqi1,2; Liu, Nan1,2; Gong, Likun1,2
刊名ACTA PHARMACEUTICA SINICA B
出版日期2024-11-01
卷号14期号:11页码:4637-4648
关键词Tumor-associated viruses Tumor microenvironment APOBEC3A Deaminase Mutation DNA damage Tumorigenesis Tumor-associated viruses Macrophage Tumor microenvironment
ISSN号2211-3835
DOI10.1016/j.apsb.2024.08.020
英文摘要The APOBEC3 (A3) family plays a pivotal role in the immune system by performing DNA/ RNA single-strand deamination. Cancers mostly arise from the accumulation of chronic mutations in somatic cells, and recent research has highlighted the A3 family as a major contributor to tumor-associated mutations, with A3A being a key driver gene leading to cancer-related mutations. A3A helps to defend the host against virus-induced tumors by editing the genome of cancer-associated viruses that invade the host. However, when it is abnormally expressed, it leads to persistent, chronic mutations in the genome, thereby fueling tumorigenesis. Notably, A3A is prominently expressed in innate immune cells, particularly macrophages, thereby affecting the functional state of tumor-infiltrating immune cells and tumor growth. Furthermore, the expression of A3A in tumor cells may directly affect their proliferation and migration. A growing body of research has unveiled that A3A is closely related to various cancers, which signifies the potential significance of A3A in cancer therapy. This paper mainly classifies and summarizes the evidence of the relationship between A3A and tumorigenesis based on the potential mechanisms, aiming to provide valuable references for further research on the functions of A3A and its development in the area of cancer therapy.
WOS关键词CYTIDINE DEAMINATION ; MUTATIONAL PROCESSES ; EDITING ENZYMES ; NUCLEAR-DNA ; CANCER ; VIRUS ; RESTRICTION ; INHIBITION ; PROTEINS ; HIV-1
资助项目Shanghai Post-doctoral Excellence Program[2022689]
WOS研究方向Pharmacology & Pharmacy
WOS记录号WOS:001364601700001
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/314798]  
专题新药研究国家重点实验室
通讯作者Gong, Likun
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yuqi,Liu, Nan,Gong, Likun. An overview of the functions and mechanisms of APOBEC3A in tumorigenesis[J]. ACTA PHARMACEUTICA SINICA B,2024,14(11):4637-4648.
APA Yang, Yuqi,Liu, Nan,&Gong, Likun.(2024).An overview of the functions and mechanisms of APOBEC3A in tumorigenesis.ACTA PHARMACEUTICA SINICA B,14(11),4637-4648.
MLA Yang, Yuqi,et al."An overview of the functions and mechanisms of APOBEC3A in tumorigenesis".ACTA PHARMACEUTICA SINICA B 14.11(2024):4637-4648.

入库方式： OAI收割

来源：上海药物研究所

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