Ring expansion of 3-hydroxyoxindoles to 4-quinolones via palladium-catalyzed C-C(acyl) bond cleavage
文献类型：期刊论文
| 作者 | Huang, Zhi-Cong1; Ruan, Zhi-Ling3; Xu, Hui1; Dai, Hui-Xiong1,2,3
|
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2024-12-17 |
| 卷号 | 61期号:1页码:109-112 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d4cc05369a |
| 英文摘要 | We report herein the construction of 4-quinolones via palladium-catalyzed regioselective beta-acyl elimination of 3-hydroxyoxindoles and a subsequent Camps cyclization process. This protocol is highly efficient and various 4-quinolone derivatives are obtained in high yields. The construction of the core skeleton of the 4-quinolone antibiotics demonstrated the synthetic utility of this method. |
| WOS关键词 | FUNCTIONALIZATION ; OPTIMIZATION ; ACTIVATION ; INHIBITORS ; AMIDATION ; KETONES ; ALKYNES |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[22171276] ; National Natural Science Foundation of China[21920102003] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[23ZR1474400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001366370800001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314804]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Zhi-Cong,Ruan, Zhi-Ling,Xu, Hui,et al. Ring expansion of 3-hydroxyoxindoles to 4-quinolones via palladium-catalyzed C-C(acyl) bond cleavage[J]. CHEMICAL COMMUNICATIONS,2024,61(1):109-112. |
| APA | Huang, Zhi-Cong,Ruan, Zhi-Ling,Xu, Hui,&Dai, Hui-Xiong.(2024).Ring expansion of 3-hydroxyoxindoles to 4-quinolones via palladium-catalyzed C-C(acyl) bond cleavage.CHEMICAL COMMUNICATIONS,61(1),109-112. |
| MLA | Huang, Zhi-Cong,et al."Ring expansion of 3-hydroxyoxindoles to 4-quinolones via palladium-catalyzed C-C(acyl) bond cleavage".CHEMICAL COMMUNICATIONS 61.1(2024):109-112. |
入库方式： OAI收割
来源：上海药物研究所
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