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Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy

文献类型：期刊论文

作者Zhai, Yihui10,12; Zhang, Wen1,11; Wang, Jinming8,9; Kong, Ying7; Rong, Rong7; Lang, Tianqun10,12; Zheng, Chao1,11; Wang, Yanke6; Yu, Yang6; Zhu, Helen He8,9
刊名ADVANCED SCIENCE
出版日期2024-12-03
页码14
关键词CTLs IL15, immunotherapy nanovesicles NK cells
DOI10.1002/advs.202409194
英文摘要Interleukin 15 (IL15) is crucial for fostering the survival and proliferation of nature killer (NK) cells and cytotoxic T lymphocytes (CTLs), playing a pivotal role in tumor control. However, IL15 supplementary therapy encounters challenges such as systemic inflammation and non-specific stimulation of cancer cells. Herein, a nanovesicle termed DoxFILN, comprising a membrane presenting IL15/IL15 receptor alpha complexes (IL15c) and a core of doxorubicin-loaded ferritin (Dox-Fn) are reported. The DoxFILN significantly enhances the densities and activities of intratumoral CTLs and NK cells. Mechanistically, DoxFILN undergoes deshelling in the acidic tumor microenvironment, releasing Dox-Fn and membrane-bound IL15c. Dox-Fn selectively target transferrin receptors on cancerous cells, facilitating intracellular Dox release and inducing immunogenic cell death. Concurrently, membrane-bound IL15c recognizes and activates IL15 receptor beta/gamma c heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16-fold and 28-fold) and NK cells (37-fold and 50-fold). The IL15-displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer.
WOS关键词T-CELLS ; MEMBRANE ; IL-15 ; RECEPTOR ; NANOPARTICLES ; FAMILY ; CHAIN ; IL15
资助项目National Key R&D Program of China ; National Natural Science Foundation of China[32371457] ; National Natural Science Foundation of China[32171374] ; National Natural Science Foundation of China[31930066] ; Shandong Laboratory Program[SYS202205] ; Chinese Academy of Sciences ; [2022YFC3401404]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号WOS:001368502300001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/314971]  
专题新药研究国家重点实验室
通讯作者Cai, Ying; Zhang, Pengcheng; Li, Yaping
作者单位1.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
2.Shanghai Clin Res & Trial Ctr, Shanghai 201203, Peoples R China
3.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China
4.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
6.Zhangjiang Lab, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China
7.Yantai Inst Mat Med, Yantai 264000, Shandong, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200127, Peoples R China
9.Shanghai Jiao Tong Univ, Ren Ji Hosp, Renji Med X Stem Cell Res Ctr, Sch Med,Dept Urol,State Key Lab Oncogenes & Relate, Shanghai 200127, Peoples R China
10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhai, Yihui,Zhang, Wen,Wang, Jinming,et al. Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy[J]. ADVANCED SCIENCE,2024:14.
APA Zhai, Yihui.,Zhang, Wen.,Wang, Jinming.,Kong, Ying.,Rong, Rong.,...&Li, Yaping.(2024).Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy.ADVANCED SCIENCE,14.
MLA Zhai, Yihui,et al."Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy".ADVANCED SCIENCE (2024):14.

入库方式： OAI收割

来源：上海药物研究所

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