Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement
文献类型：期刊论文
| 作者 | Cai, Ying7,8,9,13; Xu, Tiantian9,10; Zhu, Binyu7,9,13; Chen, Junfan11,12; Jiang, Linyang7,9,13; Shan, Xiaoting7,9,13; Rong, Rong8; Li, Yao1; Yu, Yang1; Gao, Xin2,3 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2024-11-28 |
| 页码 | 15 |
| 关键词 | drug delivery nanofilaments peptides protein adsorptions self-assembly |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202409130 |
| 英文摘要 | Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-beta plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery. |
| WOS关键词 | ALZHEIMERS-DISEASE ; CORONA ; TOXICITY ; NANOPARTICLES ; INHIBITORS |
| 资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China[32171374] ; National Natural Science Foundation of China[22273107] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[32371457] ; Chinese Academy of Sciences[Y2021076] ; Chinese Academy of Sciences[JCTD-2022-12] ; National Natural Science Foundation of Shandong Province[ZR2019ZD25] ; Shandong Laboratory Program[SYS202205] ; [2022YFC3401400] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS记录号 | WOS:001365838400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314980]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Lu; Zhang, Pengcheng; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Adv Res Inst, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China 2.King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr, Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia 3.King Abdullah Univ Sci & Technol, Comp Sci Program, Comp Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia 4.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China 5.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Biomed Engn, Shanghai 200127, Peoples R China 6.Fujian Prov Key Lab Theoret & Computat Chem, Fujian 361005, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 8.Yantai Inst Pharmaceut Sci, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China 9.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 10.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Ying,Xu, Tiantian,Zhu, Binyu,et al. Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement[J]. ADVANCED MATERIALS,2024:15. |
| APA | Cai, Ying.,Xu, Tiantian.,Zhu, Binyu.,Chen, Junfan.,Jiang, Linyang.,...&Li, Yaping.(2024).Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement.ADVANCED MATERIALS,15. |
| MLA | Cai, Ying,et al."Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement".ADVANCED MATERIALS (2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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