Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis
文献类型：期刊论文
| 作者 | Huang, Yiran; Gao, Nan; Liu, Boren6; Luo, Weili4,6; Chen, Jianfei2; Chen, Yan; Bi, Yong1; Zhou, Zikai2,3,4,5,6 |
| 刊名 | AGING AND DISEASE
 |
| 出版日期 | 2025-12-03 |
| 页码 | 20 |
| 关键词 | Monocytes Stress Bone marrow homing Adult hippocampal neurogenesis |
| ISSN号 | 2152-5250 |
| DOI | 10.14336/AD.2024.0835 |
| 英文摘要 | Adult hippocampal neurogenesis (AHN) is crucial to various brain functions. Neurodegeneration, neuroinflammation and stress can impair AHN, contributing to the development of neurological and psychiatric disorders. Stress is known to extensively affect both the brain and peripheral immune system. However, the cellular and molecular mechanisms underlying stress-induced impairments in AHN remain unclear. In this study, we found that, unlike neuroinflammatory conditions, stress significantly inhibited AHN independently of microglial activation, suggesting a novel mechanism mediating stress-impaired AHN. Since stress modulates peripheral immune cells, we examined the distribution of immune cells infiltrating the brain. We found a significant decrease of infiltrated Ly6Chi monocytes in the brain parenchyma. In the blood, adoptively transferred ZsGreen+ Ly6Chi monocytes drastically reduced due to stress-induced homing to the bone marrow. Adrenalectomy (ADX) experiments revealed that monocyte homing is regulated by glucocorticoid and may cause impairments in AHN. Depleting peripheral circulating monocytes reduced brain-resident Ly6Chi monocytes and replicated the stress-induced inhibition of AHN, independent of microglia activation. RNA sequencing analysis of Ly6Chi monocytes revealed a stress-induced transcriptional profile, suggesting their supportive role in neuronal functions. Together, these findings demonstrate a novel and essential role of brain resident Ly6Chi monocytes in maintaining AHN at basal level, which is important for brain functions. |
| WOS关键词 | LATE-LIFE DEPRESSION ; RISK-FACTOR ; ALZHEIMERS-DISEASE ; STRESS ; INFLAMMATION ; MEMORY |
| 资助项目 | Chinese Academy of Science[E2G709R0Z1] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022013] ; Zhongshan Institute for Drug Discovery[SQ2302-12] ; Guangdong High - level Innovative Research Institute[2021B0909050003] ; National Natural Science Foundation of China[82174158] ; Shanghai Pudong New Area Health Commission Clinical Characteristic Discipline Construction Plan[PWYts2021 -02] |
| WOS研究方向 | Geriatrics & Gerontology |
| WOS记录号 | WOS:001370614600001 |
| 出版者 | INT SOC AGING & DISEASE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314995]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Zikai |
| 作者单位 | 1.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 6.Guizhou Med Univ, Sch Pharm, Guiyang, Guizhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yiran,Gao, Nan,Liu, Boren,et al. Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis[J]. AGING AND DISEASE,2025:20. |
| APA | Huang, Yiran.,Gao, Nan.,Liu, Boren.,Luo, Weili.,Chen, Jianfei.,...&Zhou, Zikai.(2025).Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis.AGING AND DISEASE,20. |
| MLA | Huang, Yiran,et al."Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis".AGING AND DISEASE (2025):20. |
入库方式： OAI收割
来源：上海药物研究所
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