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An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis

文献类型：期刊论文

作者Yue, Lixia1,2; Ye, Ping9; Zhang, Yi1,5,6,7,8; Guo, Ru1,2; Xu, Weihua4; Huang, Shaogang3; Xiu, Yanfeng2; Huang, Yongzhuo1; Wang, Bing1,2
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2025
卷号284页码:13
关键词Chitosan-modified microemulsion Intestinal mucus escape Ulcerative colitis Colon mucosal healing Nobiletin
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2024.137847
英文摘要The intestinal mucus layer plays a crucial role in the systemic absorption of drugs. While penetration through this layer traditionally constitutes a pivotal phase in drug absorption, the approach for treating ulcerative colitis (UC) shifts towards facilitating the direct delivery of drugs to the colon. In this study, we engineered a chitosanmodified microemulsion encapsulated nobiletin (NOB-CS-ME) characterized by small particle dimensions and positive charge specifically, designed to enable targeted delivery. In vitro experiments demonstrated that this NOB-CS-ME effectively became less into the intestinal mucus layer, thus achieving successful escape of the intestinal mucus barrier absorption. After circumventing this barrier, NOB-CS-ME exhibited heightened cellular uptake by colonic epithelial cells, displaying an approximately 1.3-fold increase compared to the unmodified microemulsion. Collectively, these observations imply enhanced drug bioavailability, potentially resulting in more efficacious mucosal healing, providing a promising avenue for natural small-molecule drug delivery in UC treatment.
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; DRUG-DELIVERY-SYSTEMS ; ORAL DELIVERY ; NANOPARTICLES ; MUCOADHESIVE ; INHIBITION ; CARRIERS ; CELLS
资助项目National Key Research and Development Program of China (China)[2022YFE0203600] ; NFSC[81925035] ; NFSC[82341232] ; Program of Shanghai Committee of Science and Technology (China)[21ZR1475200] ; Department of Science and Technology of Guangdong Province (High-Level R&D and Innovative Research Institute)[2019B090904008] ; Department of Science and Technology of Guangdong Province (High-Level R&D and Innovative Research Institute)[2021B0909050003] ; SciTech Innovation Leading Talent Projects in Zhongshan[LJ2021001] ; Molecular Imaging Center at SIMM ; TEM at SIMM ; Flow Cytometry Facility at SIMM
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号WOS:001370122800001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/315013]  
专题新药研究国家重点实验室
通讯作者Xiu, Yanfeng; Huang, Yongzhuo; Wang, Bing
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
3.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 501405, Peoples R China
4.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Pharm, Shanghai 201318, Peoples R China
5.Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
6.Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China
7.Natl Ctr Stomatol, Shanghai 200011, Peoples R China
8.Shanghai Jiao Tong Univ, Coll Stomatol, Shanghai Peoples Hosp 9, Dept Implant Dent,Sch Med, Shanghai 200011, Peoples R China
9.Univ Shanghai Sci & Technol, Shanghai Inst Minimally Invas Therapy, Sch Med Instrument & Food Engn, Shanghai 200093, Peoples R China
推荐引用方式
GB/T 7714		 Yue, Lixia,Ye, Ping,Zhang, Yi,et al. An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,284:13.
APA Yue, Lixia.,Ye, Ping.,Zhang, Yi.,Guo, Ru.,Xu, Weihua.,...&Wang, Bing.(2025).An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,284,13.
MLA Yue, Lixia,et al."An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 284(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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