Spirocyclic iridoid alkaloids from Plumeria rubra
文献类型：期刊论文
| 作者 | Gao, Xin-Hua2; Zhou, Bin1,2; Zimbres, Flavia M.3; Zhang, Zai-Yong2; Cassera, Maria B.3; Zhao, Jin-Xin1,2; Yue, Jian-Min1,2
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 出版日期 | 2024-12-10 |
| 页码 | 7 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d4ob01870b |
| 英文摘要 | Plumerianoids A-D (1-4) with a new intact spirocyclic iridoid alkaloid skeleton, along with a new degraded alkaloid 8-epi-plumerianine (5), and a known one (6), were isolated and characterized from Plumeria rubra. The structure of 6 was revised as (8R,13S)-plumerianine. These alkaloids consist of three epimeric pairs (1/2, 3/4, and 5/6), exhibiting virtually identical NMR spectra within each pair. Furthermore, the electronic circular dichroism (ECD) curves of each epimeric pair are roughly mirror-like, reminiscent of enantiomers. This study calls for attention on the structural elucidation of special compound classes when the associated chiral centers are far away from the chromophores and/or at the terminal of the molecules. In addition, compound 3 exhibited moderate antiplasmodial activity. |
| WOS关键词 | CHEMICAL-CONSTITUENTS ; FLOWERS |
| 资助项目 | National Key Research and Development Program of China[2023YFE0206100] ; National Key Research and Development Program of China[22ZR1473600] ; Science and Technology Commission of Shanghai Municipality[2022282] ; Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[SIMM0120231002] ; Shanghai Institute of Materia Medica of CAS |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001375898400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315025]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Dept Biochem & Mol Biol, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Gao, Xin-Hua,Zhou, Bin,Zimbres, Flavia M.,et al. Spirocyclic iridoid alkaloids from Plumeria rubra[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2024:7. |
| APA | Gao, Xin-Hua.,Zhou, Bin.,Zimbres, Flavia M..,Zhang, Zai-Yong.,Cassera, Maria B..,...&Yue, Jian-Min.(2024).Spirocyclic iridoid alkaloids from Plumeria rubra.ORGANIC & BIOMOLECULAR CHEMISTRY,7. |
| MLA | Gao, Xin-Hua,et al."Spirocyclic iridoid alkaloids from Plumeria rubra".ORGANIC & BIOMOLECULAR CHEMISTRY (2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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