C(sp3)-H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives
文献类型：期刊论文
| 作者 | Wang, Kai1; Ouyang, Jun1; Liu, Huan1; Yin, Lijun1; Yang, Kuoqi1; Lan, Lefu1; Hu, Youhong1,2 ; Hu, Naifu1,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2024-12-10 |
| 卷号 | 89期号:24页码:18746-18751 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.4c02443 |
| 英文摘要 | A novel method is reported to synthesize various pyrazolones through transition-metal-free and redox-neutral 1 degrees, 2 degrees, or 3 degrees C(sp3)-H carbonylative cyclization using 1 atm of CO2 as a green carbonyl source, featuring good functional group tolerance, a broad substrate scope, facile scalability, and easy product transformation. The utility of this method could be demonstrated by the applications in preparing useful synthetic intermediates and bioactive compounds. |
| WOS关键词 | TRANSITION-METAL-FREE ; C-H BONDS ; CARBON-DIOXIDE ; N-TOSYLHYDRAZONES ; SUBSTITUTED PYRAZOLONES ; CATALYZED CARBONYLATION ; BIOLOGICAL-ACTIVITY ; DESIGN ; CARBOXYLATION ; LACTAMIZATION |
| 资助项目 | Natural Science Foundation of Zhejiang Province[2022ZZ01018] ; Natural Science Foundation of Zhejiang Province[2023HIAS-V006] ; Research Funds of Hangzhou Institute for Advanced Study, UCAS[LBMHZ24B060007] ; Zhejiang Provincial Natural Science Foundation of China |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:001374178100001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315034]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hu, Naifu |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kai,Ouyang, Jun,Liu, Huan,et al. C(sp3)-H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives[J]. JOURNAL OF ORGANIC CHEMISTRY,2024,89(24):18746-18751. |
| APA | Wang, Kai.,Ouyang, Jun.,Liu, Huan.,Yin, Lijun.,Yang, Kuoqi.,...&Hu, Naifu.(2024).C(sp3)-H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives.JOURNAL OF ORGANIC CHEMISTRY,89(24),18746-18751. |
| MLA | Wang, Kai,et al."C(sp3)-H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives".JOURNAL OF ORGANIC CHEMISTRY 89.24(2024):18746-18751. |
入库方式： OAI收割
来源：上海药物研究所
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