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Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions

文献类型：期刊论文

作者Zhu JC(朱婧辰)4,5,6; Chen SB(陈深宝)4,5,6; Zhou LW(周吕文)3,4,5,6; Gong, Xiaobo2; Cui, Yuhong1; Zhang Y(章燕)4,5,6; Long M(龙勉)4,5,6; Lv SQ(吕守芹)4,5,6
刊名BIOPHYSICAL JOURNAL
出版日期2025-02-04
卷号124期号:3页码:480-493
ISSN号0006-3495
DOI10.1016/j.bpj.2024.11.3315
通讯作者Long, Mian(mlong@imech.ac.cn) ; Lu, Shouqin(lsq@imech.ac.cn)
英文摘要It is interesting to find pathologically that leukocytes, especially neutrophils, tend to adhere in the liver sinusoids dominantly but not in the postsinusoidal venules. While both views of receptor-ligand interactions and physical trapping are proposed for mediating leukocyte adhesion in liver sinusoids, integrated investigations for classifying their respective contributions are poorly presented. With a combination of Monte Carlo simulation and immersed boundary method, this study explored numerically the effects of molecular interaction kinetics and sinusoidal mechanical properties on leukocyte adhesion in liver sinusoid jointly. Results showed that, within the range of biological limitations, the lumen stenosis ratio, leukocyte stiffness, Disse space stiffness and endothelium permeability regulate the comprehensive adhesion process in a descending order of significance in the presence of receptor-ligand interactions. While leukocyte adhesions could be mutually promoted with proper combinations of leukocyte stiffness, lumen stenosis, and molecular interaction, the binding affinity is insensitive under the conditions with low leukocyte stiffness in normal lumen stenosis and high leukocyte stiffness in high lumen stenosis. This work deepens the understanding of recruitment mechanism of leukocyte in liver sinusoids.
分类号一类/力学重要期刊
WOS关键词HEPATIC MICROCIRCULATION ; P-SELECTIN ; CELL ; SIMULATION ; FLOW ; DEFORMABILITY ; RECRUITMENT ; DYNAMICS ; NEUTROPHILS ; HYALURONAN
资助项目National Natural Science Foundation of China[T2394512] ; National Natural Science Foundation of China[32130061] ; National Natural Science Foundation of China[12172366] ; National Natural Science Foundation of China[12072198] ; Scientific Instrument Developing Project of Chinese Academy of Sciences[GJJSTD20220002]
WOS研究方向Biophysics
语种英语
WOS记录号WOS:001422868800001
资助机构National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences
其他责任者龙勉 ; 吕守芹
源URL[http://dspace.imech.ac.cn/handle/311007/100119]  
专题力学研究所_国家微重力实验室
作者单位1.Tianjin Univ, Dept Mech, Tianjin, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Naval Architecture Ocean & Civil Engn, Dept Engn Mech, Key Lab Hydrodynam,Minist Educ, Shanghai, Peoples R China;
3.Ningbo Univ, Sch Mech Engn & Mech, Smart Mat & Adv Struct Lab, Ningbo, Zhejiang, Peoples R China;
4.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China;
5.Chinese Acad Sci, Inst Mech, CAS Ctr Excellence Complex Syst Mech, Beijing, Peoples R China;
6.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Key Lab Micrograv,Natl Micrograv Lab,Beijing Key L, Beijing, Peoples R China;
推荐引用方式
GB/T 7714		 Zhu JC,Chen SB,Zhou LW,et al. Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions[J]. BIOPHYSICAL JOURNAL,2025,124(3):480-493.
APA 朱婧辰.,陈深宝.,周吕文.,Gong, Xiaobo.,Cui, Yuhong.,...&吕守芹.(2025).Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions.BIOPHYSICAL JOURNAL,124(3),480-493.
MLA 朱婧辰,et al."Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions".BIOPHYSICAL JOURNAL 124.3(2025):480-493.

入库方式： OAI收割

来源：力学研究所

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