Hydrologically-induced landslides are ubiquitous natural hazards in the Himalayas, posing severe threat to human life and infrastructure. Yet, landslide assessment in the Himalayas is extremely challenging partly due to complex and drastically changing climate conditions. Here we establish a mechanistic hydromechanical landslide modeling framework that incorporates the impacts of key water fluxes and stocks on landslide triggering and risk evolution in mountain systems, accounting for potential climate change conditions for the period 1991-2100. In the drainage basin of the largest river in the northern Himalayas- the Yarlung Zangbo River Basin (YZRB), we estimate that rainfall, glacier/snow melt and permafrost thaw contribute similar to 38.4%, 28.8%, and 32.8% to landslides, respectively, for the period 1991-2019. Future climate change will likely exacerbate landslide triggering primarily due to increasing rainfall, whereas the contribution of glacier/snow melt decreases owing to deglaciation and snow cover loss. The total Gross Domestic Productivity risk is projected to increase continuously throughout the 21st century, while the risk to population shows a general declining trend. The results yield novel insights into the climatic controls on landslide evolution and provide useful guidance for disaster risk management and resilience building under future climate change in the Himalayas.