Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice
文献类型：期刊论文
| 作者 | Li, Huan2,3,5; Xu, Shimin1,2; Zhou, Feng4; Liu, Su1,2,3; Zhang, Dong1,2; Wei, Xuanyi3 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 288页码:10 |
| 关键词 | Polystyrene microplastics (PSMPs) Infant mice Oral exposure Intestinal barrier impairment Hepatic injury |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2024.117357 |
| 英文摘要 | The pervasive presence of microplastics (MPs) in infant formula and care products has emerged as a significant and underappreciated risk to public health. Notably, infants are at an elevated risk due to their underdeveloped intestinal defenses and liver detoxification capabilities, factors that could heighten their vulnerability to MPs. This study presents a comprehensive evaluation of the health implications linked to polystyrene microplastics (PSMPs) exposure during early life, examining both environmentally plausible and elevated levels. Based on histological analysis, in vivo imaging analysis, biochemical analysis and 16S rRNA sequencing results, our study found that oral PSMPs exposure in infant mice led to profound toxicological consequences, such as intestinal barrier impairment and hepatic injury, in a dose-dependent manner. Strikingly, even low ambient concentration of PSMPs (20 ppb) was sufficient to inflict considerable harm, disrupting the intestinal barrier, manifested that lessened mucus secretion, elevated iFABP level (276.50+10.73 pg/mL), decreased sIgA levels (0.60+0.03 mg/g), and pathological damage of intestinal tissues, allowing PSMPs accumulation and leakage into blood, inducing hepatotoxicity, such as increased TG levels (0.99+0.05 mmol/gprot) and lipid droplet accumulation. Furthermore, PSMPs exposure gives rise to aberrant bacterial colonization, dropping the abundance of probiotics as well as altering the abundance of pathogenic bacteria, which may contribute to the toxicity outcomes. The study underscores the critical need for vigilance regarding the insidious effects of PSMPs at environmental-relevant concentrations, especially in the context of infant exposure. |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001363746600001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/82007]  |
| 专题 | 中国科学院广州地球化学研究所 |
| 通讯作者 | Liu, Su |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Prov Key Lab Environm Protect & Resource, Guangzhou 510640, Peoples R China 2.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China 3.China Pharmaceut Univ, Sch Engn, Nanjing 211198, Peoples R China 4.Nanjing Xiaozhuang Univ, Sch Food Sci, Nanjing 211171, Peoples R China 5.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Huan,Xu, Shimin,Zhou, Feng,et al. Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,288:10. |
| APA | Li, Huan,Xu, Shimin,Zhou, Feng,Liu, Su,Zhang, Dong,&Wei, Xuanyi.(2024).Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,288,10. |
| MLA | Li, Huan,et al."Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 288(2024):10. |
入库方式： OAI收割
来源：广州地球化学研究所
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