Profiling metabolites and exploring metabolism of parabens in human urine using non-target screening and molecular networking
文献类型：期刊论文
| 作者 | Yang, Tao3,4; Li, Xinling3,4; Tan, Jianhua2; Liang, Wenyao2; Kuang, Hongxuan1; Peng, Xianzhi4 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2024-12-05 |
| 卷号 | 480页码:10 |
| 关键词 | Parabens Non-target screening Molecular network Metabolic pathway Human urine |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2024.135807 |
| 英文摘要 | Parabens are widely used as preservatives in food, pharmaceuticals, and cosmetics due to their excellent antimicrobial activities, cost-effectiveness, and stability. Previous studies have demonstrated their harmful potential and ubiquity in the environment and human tissues. This study revealed profiles of parabens and their metabolites in urine samples from a general population of different ages in China using non-target screening. Metabolism of parabens in human bodies was further explored through the identified metabolites in combination of molecular networking. A total of 34 paraben compounds were screened in the urine samples. In addition to 3 identified confidence level 1 (CL1) parent parabens, 3 CL2 compounds were also identified, namely 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, and ethylparaben sulfate. Furthermore, 6 CL3 compounds were tentatively identified, five of which were sulfonated and sulfated metabolites of parabens. The remaining 22 were CL4 features without certain chemical structures. Hazardousness assessment suggested toxic potential of the identified metabolites. Distribution of the parabens and metabolites in the urines showed age-dependent differences. Sulfonation and sulfation were potentially significant metabolic pathways of the parabens in human bodies. This study provides a new insight into understanding metabolism of parabens in human bodies and potential risks of human exposure to parabens. |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001315860500001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/81137]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Peng, Xianzhi |
| 作者单位 | 1.South China Inst Environm Sci, Minist Environm Protect, State Environm Protect Key Lab Environm Pollut Hl, Guangzhou 510655, Guangdong, Peoples R China 2.Guangzhou Qual Supervis & Testing Inst, Guangzhou 510050, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangdong Prov Key Lab Environm Protect & Resource, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Tao,Li, Xinling,Tan, Jianhua,et al. Profiling metabolites and exploring metabolism of parabens in human urine using non-target screening and molecular networking[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,480:10. |
| APA | Yang, Tao,Li, Xinling,Tan, Jianhua,Liang, Wenyao,Kuang, Hongxuan,&Peng, Xianzhi.(2024).Profiling metabolites and exploring metabolism of parabens in human urine using non-target screening and molecular networking.JOURNAL OF HAZARDOUS MATERIALS,480,10. |
| MLA | Yang, Tao,et al."Profiling metabolites and exploring metabolism of parabens in human urine using non-target screening and molecular networking".JOURNAL OF HAZARDOUS MATERIALS 480(2024):10. |
入库方式： OAI收割
来源：广州地球化学研究所
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