中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport

文献类型:期刊论文

作者Zhu, Chunyou2,5; Cao, Zhiguo5; Hu, Beibei1; Li, Zhi1; Huang, Simin4; Han, Xu5; Luo, Xiaojun3; Yuan, Haoran2; Li, Liangzhong2
刊名ENVIRONMENT INTERNATIONAL
出版日期2024-10-01
卷号192页码:8
关键词Chlorinated paraffins Dermal exposure Bare skin Clothing-covered skin areas Oral ingestion
ISSN号0160-4120
DOI10.1016/j.envint.2024.109068
英文摘要To investigate human exposure to short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) through dermal and oral intake via hand-to-mouth contact, wipes from the face, forearm, hand, and foot of 30 volunteers were sampled. The concentration of SCCPs and MCCPs ranged from 0.66 to 119 and 0.71 to 565 mu g/m2, respectively. Hands exhibited significantly higher CPs concentrations than other skin areas, indicating that direct contact with indoor surfaces contributed considerable CP levels on this bare skin area. Gender differences in CP levels were observed in wipes from all locations, except for the hands, possibly because of the significant variability in residuals on the hands. A significant positive relationship was found between CP levels on the hands and faces, and the CP ratios of the hands/faces were related to log KOA. Bare skin showed more significant variations in CP partitioning among related congeners and between genders than skin covered by clothing, as elucidated by the linear analysis of RSD and log KOA. Although concentrations on clothing-covered areas were relatively lower than on bare skin, the median estimated dermal absorption doses of SCCPs and MCCPs (152 and 737 ng/kg bw/day, respectively) for the entire body were approximately 1-2 orders of magnitude higher than those for oral ingestion (1.62 and 7.94 ng/kg bw/day, respectively), emphasizing indirect dermal uptake as a significant exposure pathway for humans.
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001336532600001
源URL[http://ir.gig.ac.cn/handle/344008/81231]  
专题有机地球化学国家重点实验室
通讯作者Li, Liangzhong
作者单位1.Southern Marine Sci & Engn Guangdong Lab Guangzhou, Guangzhou 511458, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangdong Prov Key Lab High Qual Recycling End Lif, Guangzhou 510640, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangdong Prov Key Lab Environm Protect & Resource, Guangzhou 510640, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Guangzhou 510260, Peoples R China
5.Henan Normal Univ, Sch Environm, Key Lab Yellow River & Huai River Water Environm &, Minist Educ, Xinxiang 453007, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Chunyou,Cao, Zhiguo,Hu, Beibei,et al. Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport[J]. ENVIRONMENT INTERNATIONAL,2024,192:8.
APA Zhu, Chunyou.,Cao, Zhiguo.,Hu, Beibei.,Li, Zhi.,Huang, Simin.,...&Li, Liangzhong.(2024).Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport.ENVIRONMENT INTERNATIONAL,192,8.
MLA Zhu, Chunyou,et al."Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport".ENVIRONMENT INTERNATIONAL 192(2024):8.

入库方式: OAI收割

来源:广州地球化学研究所

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