Molecular characteristics of organic matters in PM 2.5 associated with upregulation of respiratory virus infection in vitro
文献类型：期刊论文
| 作者 | Lin, Juying2,3,4; Sun, Wei1,2,3; Peng, Shuyi2,3,4; Hu, Yaohao2,3,4; Zhang, Guohua1,2,3 ; Song, Wei1,2,3; Jiang, Bin1,2,3; Liao, Yuhong1,2,3; Pei, Chenglei5; Zhang, Jinpu5
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2025-01-15 |
| 卷号 | 482页码:10 |
| 关键词 | ACE2 FT-ICR MS SARS-CoV-2 Water-soluble organic matters Water-insoluble organic matters |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2024.136583 |
| 英文摘要 | The extent to which organic matters (OM) in PM 2.5 affect virus infections and the key organic molecules involved in this process remain unclear. Herein, this study utilized ultra-high resolution mass spectrometry coupled with in vitro experiments to identify the organic molecules associated with respiratory virus infection for the first time. Water-soluble organic matters (WSOM) and water-insoluble organic matters (WIOM) were separated from PM 2.5 samples collected at the urban area of Guangzhou, China. Their molecular compositions were analyzed using Fourier transform ion cyclotron resonance mass spectrometry. Subsequently, in vitro experiments were conducted to explore the impact of WSOM and WIOM exposure on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudo-virus infection in A549 cells. Results revealed that WSOM and WIOM respectively promoted 1.7 to 2.1-fold and 1.9 to 3.5-fold upregulation of SARS-CoV-2 pseudo-virus infection in a concentration- dependent manner (at 25 to 100 mu g mL-1) compared to the virus-only control group. Partial least squares model analysis indicated that the increased virus infection was likely related to phthalate ester and nitro-aromatic molecules in WSOM, as well as LipidC molecules with aliphatic and olefinic structures in WIOM. Interestingly, the molecules responsible for upregulating SARS-CoV-2 receptor angiotensin-converting enzyme 2 ( ACE2 ) expression and virus infection differed. Thus, it was concluded that ACE2 upregulation alone may not fully elucidate the mechanisms underlying increased susceptibility to virus infection. The findings highlight the critical importance of aromatic and lipid molecules found in OM in relation to respiratory virus infection. |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001364270200001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/82010]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Bi, Xinhui |
| 作者单位 | 1.Guangdong Hong Kong Macao Joint Lab Environm Pollu, Hong Kong 510640, Guangdong, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 3.Guangzhou Inst Geochem, Chinese Acad Sci, Guangdong Prov Key Lab Environm Protect & Resource, Guangzhou 510640, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Environm Monitoring Ctr, Guangzhou Sub Branch Guangdong Ecol, Guangzhou 510006, Peoples R China 6.Guangzhou Med Univ, Guangzhou Inst Biomed, Hlth GMU GIBH Joint Sch Life Sci, Guangzhou 510436, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Juying,Sun, Wei,Peng, Shuyi,et al. Molecular characteristics of organic matters in PM 2.5 associated with upregulation of respiratory virus infection in vitro[J]. JOURNAL OF HAZARDOUS MATERIALS,2025,482:10. |
| APA | Lin, Juying.,Sun, Wei.,Peng, Shuyi.,Hu, Yaohao.,Zhang, Guohua.,...&Bi, Xinhui.(2025).Molecular characteristics of organic matters in PM 2.5 associated with upregulation of respiratory virus infection in vitro.JOURNAL OF HAZARDOUS MATERIALS,482,10. |
| MLA | Lin, Juying,et al."Molecular characteristics of organic matters in PM 2.5 associated with upregulation of respiratory virus infection in vitro".JOURNAL OF HAZARDOUS MATERIALS 482(2025):10. |
入库方式： OAI收割
来源：广州地球化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。