"3D channel maze" to control drug release from multiple unit tablets
文献类型：期刊论文
| 作者 | Xu, Huipeng8,9; Zhang, Liu6,9; Fang, Longwei2,9; He, Dunwei5; York, Peter1,9; Sun, Lixin6; Niu, Jianzhao4; Liu, Qian4; Xu, Mingdi4; Xue, Yanling3 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2025-02-10 |
| 卷号 | 378页码:236-246 |
| 关键词 | Controlled release Channel maze Theophylline Three dimension Synchrotron radiation |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2024.12.014 |
| 通讯作者 | Yin, Xianzhen(xzyin@lglab.ac.cn) ; Wu, Li(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Diffusion is defined as general mechanism for drug release from advanced delivery systems, yet dynamic structure of dosage form intrinsically plays an unknown role. The synchrotron radiation X-ray micro-computed tomography (SR-mu CT) three-dimensional (3D) imaging and in-depth analysis of 3D structures were applied to readily differentiate materials and accurately capture internal structure changes of multiple unit pellet system (MUPS) and the constituent pellets, visualizing internal 3D structure of a MUPS of theophylline tablets for their 3 levels hierarchy structures: pellets with rapid drug release characteristics, a protective cushion layer and a matrix layer. Drug release pathways were extracted from SR-mu CT images and a 3D maze network was constructed using pore network analysis to quantify the internal structural evolution during drug release. In the initial stage of dissolution about 1 h, theophylline release from the MUPS is dominated by diffusion from the matrix layer, whilst the second phase of 23 h constant release kinetics is dominated by a 3D channel maze architecture with outlets/channels connecting pellets in the remains of the MUPS, which forms the 3D channel maze as pore networks. The random walking of the dissolved theophylline molecules retarded by the tortuous 3D channel maze which led to the observed controlled release profile as a whole. Based on SR-mu CT investigations and 3D structure analysis, a new approach to control drug release via a 3D channel maze structure was discovered. |
| WOS关键词 | OSMOTIC PUMP TABLETS ; THEOPHYLLINE ANHYDRATE ; PELLETS ; SYSTEM ; FORMULATION ; TOMOGRAPHY ; METOPROLOL ; DIFFUSION ; KINETICS ; CHITOSAN |
| 资助项目 | National Natural Science Foundation of China (China)[82273863] ; Shanghai Excellent Academic Leader (Youth)[23XD1460400] ; Rikaze City 2024 Regional Science and Technology Collaborative Innovation Special Project[QYXTZX-RKZ2024-01-1] ; Discipline Leading Talent Project of Tibet University[00061243/047] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001388762100001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315597]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yin, Xianzhen; Wu, Li; Zhang, Jiwen |
| 作者单位 | 1.Univ Bradford, Sch Pharm, Bradford BD7 1DP, West Yorkshire, England 2.Tibet Univ, High Altitude Hlth Sci Res Ctr, Lhasa 850000, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 4.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China 5.Shandong Hiqual Pharmatech Co Ltd, Zibo 255035, Peoples R China 6.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang 110016, Peoples R China 7.Lingang Lab, Shanghai 201602, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Huipeng,Zhang, Liu,Fang, Longwei,et al. "3D channel maze" to control drug release from multiple unit tablets[J]. JOURNAL OF CONTROLLED RELEASE,2025,378:236-246. |
| APA | Xu, Huipeng.,Zhang, Liu.,Fang, Longwei.,He, Dunwei.,York, Peter.,...&Zhang, Jiwen.(2025)."3D channel maze" to control drug release from multiple unit tablets.JOURNAL OF CONTROLLED RELEASE,378,236-246. |
| MLA | Xu, Huipeng,et al.""3D channel maze" to control drug release from multiple unit tablets".JOURNAL OF CONTROLLED RELEASE 378(2025):236-246. |
入库方式： OAI收割
来源：上海药物研究所
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