Engineered extracellular vesicles loaded in boronated cyclodextrin framework for pulmonary delivery
文献类型：期刊论文
| 作者 | Ren, Xiaohong3,4,5; Wang, Siwen1,3; Teng, Yupu2; Zheng, Shiyu3; Li, Feng1,3; Wang, Caifen2,3; Wu, Li3; Zhang, Jiwen1,2,3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-03-15 |
| 卷号 | 352页码:11 |
| 关键词 | Extracellular vesicles RGD Anti-inflammation Pulmonary delivery Boronated cyclodextrin framework |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.123160 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Extracellular vesicles (EVs) are promising therapeutic carriers for their ideal nano-size and intrinsic biocompatibility, while rapid clearance and limited targeting ability are the major setbacks of EVs. With minimal absorption into the systemic circulation, inhalation for pulmonary disease therapy minimizes off-target toxicity to other organs and offers a safe and effective treatment for respiratory disorders. Herein, a nano-grid carrier made of boronated cyclodextrin framework (BCF) was prepared for pH/H2O2 responsive release of EVs. A novel design of cyclo (Arg-Gly-Asp-D-Tyr-Lys) peptide (RGD)-modified milk-derived EVs (mEVs) loaded in the BCF particles (RGD-mEVs@BCF) was developed for pulmonary delivery. The results indicated that RGD-mEVs showed superior anti-inflammatory activity in contrast with mEVs in vitro. BCF was able to capture and protect RGD-mEVs, which showed extended-release profiles and responsiveness. Pulmonary administration of RGD-mEVs@BCF showed favorable biocompatibility in rats. Taken together, RGD-mEVs@BCF features biocompatibility and pH-responsive mEVs release as a therapeutic platform for pulmonary delivery of drugs to treat lung diseases, especially for inflammatory diseases. |
| WOS关键词 | CD-MOF |
| 资助项目 | National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001394438500001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315639]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 4.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 5.Macau Univ Sci & Technol, Fac Med, Sch Pharm, Macau 999078, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Xiaohong,Wang, Siwen,Teng, Yupu,et al. Engineered extracellular vesicles loaded in boronated cyclodextrin framework for pulmonary delivery[J]. CARBOHYDRATE POLYMERS,2025,352:11. |
| APA | Ren, Xiaohong.,Wang, Siwen.,Teng, Yupu.,Zheng, Shiyu.,Li, Feng.,...&Zhang, Jiwen.(2025).Engineered extracellular vesicles loaded in boronated cyclodextrin framework for pulmonary delivery.CARBOHYDRATE POLYMERS,352,11. |
| MLA | Ren, Xiaohong,et al."Engineered extracellular vesicles loaded in boronated cyclodextrin framework for pulmonary delivery".CARBOHYDRATE POLYMERS 352(2025):11. |
入库方式： OAI收割
来源：上海药物研究所
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