中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Robust Whole-Cell-Based Chemoenzymatic Synthesis of Site-Selective Deuterated α-Hydroxy Acids and α-Amino Acids

文献类型：期刊论文

作者Yu, Keying2,3; Liu, Yanqiong2,3; Zhang, Jingxuan1,2; Zhao, Wushuang1,2; Mao, Yingle2; Liao, Cangsong2,3
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2024-11-20
页码11
关键词Deuteration Biocatalysis Chemoenzymatic synthesis Asymmetric synthesis Amino acids
ISSN号1615-4150
DOI10.1002/adsc.202401330
通讯作者Mao, Yingle(maoyingle@simm.ac.cn) ; Liao, Cangsong(csliao@simm.ac.cn)
英文摘要Deuterated hydroxyl acids and amino acids have been widely utilized in life science, biochemistry and drug development. Site-selective and stereoselective synthesis of deuterated hydroxyl acids and amino acids remains a significant challenge. Here, we report the development of a robust whole-cell-based chemoenzymatic platform for the synthesis of deuterated hydroxyl acids and amino acids from off-the-shelf aldehydes in high yields with excellent selectivities and levels of deuteration. The platform delivers products with diverse scaffolds and deuteration patterns, as well as broad scopes with both aromatic and aliphatic side chains. The application of the platform was demonstrated by the concise synthesis of a deuterium-containing antiparkinson's disease candidate. This platform provides a concrete foundation for accessing amino acid isotopologs for potential applications in research and drug discovery and development.
WOS关键词DEUTERIUM ; DRUG ; AMINOTRANSFERASE ; PEPTIDE
资助项目Shanghai Institute of Materia Medica and Chinese Academy of Sciences ; National Natural Science Foundation of China (NSFC)[22161132029] ; National Natural Science Foundation of China (NSFC)[22071259]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001393232100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/315642]  
专题中国科学院上海药物研究所
通讯作者Mao, Yingle; Liao, Cangsong
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Keying,Liu, Yanqiong,Zhang, Jingxuan,et al. Robust Whole-Cell-Based Chemoenzymatic Synthesis of Site-Selective Deuterated α-Hydroxy Acids and α-Amino Acids[J]. ADVANCED SYNTHESIS & CATALYSIS,2024:11.
APA Yu, Keying,Liu, Yanqiong,Zhang, Jingxuan,Zhao, Wushuang,Mao, Yingle,&Liao, Cangsong.(2024).Robust Whole-Cell-Based Chemoenzymatic Synthesis of Site-Selective Deuterated α-Hydroxy Acids and α-Amino Acids.ADVANCED SYNTHESIS & CATALYSIS,11.
MLA Yu, Keying,et al."Robust Whole-Cell-Based Chemoenzymatic Synthesis of Site-Selective Deuterated α-Hydroxy Acids and α-Amino Acids".ADVANCED SYNTHESIS & CATALYSIS (2024):11.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。