Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston
文献类型：期刊论文
| 作者 | Liu, Zhilong2,3; Huang, Yuepei2,3; Chen, Jieting2,3; Peng, Lihua1; Qiao, Weilin1; Li, Wei2,3; Guo, De-an2,3
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-03-01 |
| 卷号 | 181页码:7 |
| 关键词 | Syzygium jambos Pentacyclic triterpenoids Oleanane Ursane Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.106346 |
| 通讯作者 | Li, Wei(liwei1@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Phytochemical investigation of the stems of Syzygium jambos (L.) Alston resulted in the isolation of five new pentacyclic triterpenoids, including three oleananes (1, 2 , and 5 ) and two ursanes (3 and 4 ), along with 23 known compounds (6-28). Their structures were elucidated by comprehensive spectroscopic analysis and chemical methods. All isolated compounds were evaluated for their cytotoxic activities against two lung carcinoma cell lines, H1975 and HCC827. Among them, compounds 2 , 7 , 11 , 13-16, 18 , and 23 exhibited significant cytotoxic activities against H1975 and/or HCC827 cells, with IC50 values below 10 mu M. Furthermore, the preliminary structure-activity relationships of these pentacyclic triterpenoids are also discussed. |
| WOS关键词 | ANTIINFLAMMATORY ACTIVITY ; ANTIOXIDANT ; LEAVES ; ACID ; DERIVATIVES ; EXTRACT ; ROOTS |
| 资助项目 | Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001394655700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315657]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Wei; Guo, De-an |
| 作者单位 | 1.Zhongshan Zhongzhi Pharmaceut Grp Co Ltd, Zhongshan 528400, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhilong,Huang, Yuepei,Chen, Jieting,et al. Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston[J]. FITOTERAPIA,2025,181:7. |
| APA | Liu, Zhilong.,Huang, Yuepei.,Chen, Jieting.,Peng, Lihua.,Qiao, Weilin.,...&Guo, De-an.(2025).Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston.FITOTERAPIA,181,7. |
| MLA | Liu, Zhilong,et al."Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston".FITOTERAPIA 181(2025):7. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。