A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy
文献类型：期刊论文
| 作者 | Zeng, Shuang7,8; Chen, Chen6; Yu, Dan5; Jiang, Maojun4; Li, Xin4; Liu, Xiaosheng7; Guo, Zhihan7; Hao, Yifu7; Zhou, Danhong8; Kim, Heejeong3 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2025-01-13 |
| 页码 | 17 |
| 关键词 | hemicyanine dyes immunogenic cell death immunotherapy photodynamic therapy photon-driven pyroptosis |
| DOI | 10.1002/advs.202409007 |
| 通讯作者 | Wang, Jingyun(wangjingyun67@dlut.edu.cn) ; Chen, Qixian(plasmid@zju.edu.cn) ; Li, Haidong(lihd@dlut.edu.cn) ; Yoon, Juyoung(jyoon@ewha.ac.kr) |
| 英文摘要 | Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics. Herein, using the targeted group-assisted strategy (TAGS), an intriguing cyclooxygenase-2-targeted photodynamic conjugate, Indo-Cy, strategically created, which exploits the enzyme's overabundance in the tumoral ER, especially under proinflammatory hypoxic conditions. This conjugate, with its highly precise ER imaging, embodies a trifunctional strategy: i) innovating an electron transfer mechanism, converting the hemicyanine moiety into an oxygen-independent type I photosensitizer, thereby navigating around the hypoxia constraints of traditional PDT; ii) executing precise ER-targeted PDT, amplifying caspase-1/GSDMD-mediated pyroptosis for ICD; 3) attenuating immunosuppressive pathways by inhibiting cyclooxygenase-2 downstream factors, including HIF-1 alpha, PGE2, and VEGF. Indo-Cy's multimodal approach potently induces in vivo tumor pyroptosis and bolsters antitumor immunity, underscoring cyclooxygenase-2-targeted dyes' potential as a versatile oncotherapeutics. |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; MACROPHAGE POLARIZATION ; MYELOID CELLS ; COX-2 ; HYPOXIA ; PHOTOSENSITIZERS ; INFLAMMATION ; EXPRESSION |
| 资助项目 | National Key Research and Development Program ; National Natural Science Foundation of China[22078050] ; National Natural Science Foundation of China[22378050] ; National Natural Science Foundation of China[22378051] ; National Natural Science Foundation of China[22090011] ; Science and Technology Plan Project of Liaoning Province[2023JH2/101700296] ; Postdoctoral Fellowship Program of CPSF[GZC20240182] ; Fundamental Research Funds for the Central Universities[DUT24ZD117] ; Fundamental Research Funds for the Central Universities[DUT24LAB105] ; Fundamental Research Funds for the Central Universities[DUT22LAB601] ; National Research Foundation of Korea - Korean government (MSIT)[2022R1A2C3005420] ; National Research Foundation of Korea - Korean government (MSIT)[RS-2023-00217701] ; Korea Basic Science Institute (National Research Facilities and Equipment Center) - Ministry of Education[2020R 1A 6C 101B194] ; [2022YFD1700200] ; [2023YFB3810300] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001395383200001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315669]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Jingyun; Chen, Qixian; Li, Haidong; Yoon, Juyoung |
| 作者单位 | 1.Zhejiang Univ, Innovat Ctr Yangtze River Delta, Jiaxing 314100, Peoples R China 2.Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea 3.Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea 4.Dalian Univ Technol, Sch Chem, Dalian 116024, Peoples R China 5.Naval Med Univ, Shanghai Changzheng Hosp, Shanghai 20000, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 7.Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Hitech Zone, Dalian 116024, Peoples R China 8.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd,Hitech Zone, Dalian 116024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Shuang,Chen, Chen,Yu, Dan,et al. A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy[J]. ADVANCED SCIENCE,2025:17. |
| APA | Zeng, Shuang.,Chen, Chen.,Yu, Dan.,Jiang, Maojun.,Li, Xin.,...&Yoon, Juyoung.(2025).A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy.ADVANCED SCIENCE,17. |
| MLA | Zeng, Shuang,et al."A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy".ADVANCED SCIENCE (2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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