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Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery

文献类型：期刊论文

作者Li, Heng6,7; He, Jipei5; Hou, Jie7; He, Chengjun7; Dai, Xiaojiang7; Song, Zhigao4; Liu, Qing3; Wang, Zixin7; Huang, Hongyan7; Ding, Yunfa7
刊名FRONTIERS IN ENDOCRINOLOGY
出版日期2025-01-08
卷号15页码:13
关键词duodenal jejunal bypass type 2 diabetes mellitus gut microbiota gut barrier metabonomics bariatric surgery
ISSN号1664-2392
DOI10.3389/fendo.2024.1456885
通讯作者Zhang, Hongbin(zhangwater@hotmail.com) ; Wu, Liangping(drwulp@163.com)
英文摘要Bariatric surgery is an effective treatment for type 2 Diabetes Mellitus (T2DM), yet the precise mechanisms underlying its effectiveness remain incompletely understood. While previous research has emphasized the role of rearrangement of the gastrointestinal anatomy, gaps persist regarding the specific impact on the gut microbiota and barriers within the biliopancreatic, alimentary, and common limbs. This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on obese T2DM mice. We performed DJB and SHAM surgery in obese T2DM mice to investigate changes in the gut microbiota and barrier across different intestinal limbs. The effects on serum metabolism and potential associations with T2DM improvement were also investigated. Following DJB surgery, there was an increased abundance of commensals across various limbs. Additionally, the surgery improved intestinal permeability and inflammation in the alimentary and common limbs, while reducing inflammation in the biliopancreatic limbs. Furthermore, DJB surgery also improved T2DM by increasing L-glutamine, short-chain fatty acids, and bile acids and decreasing branched-chain amino acids. This study underscores the role of intestinal rearrangement in reshaping gut microbiota composition and enhancing gut barrier function, thereby contributing to the amelioration of T2DM following bariatric surgery, and providing new insights for further research on bariatric surgery.
WOS关键词HUMAN GUT MICROBIOTA ; INDUCED WEIGHT-LOSS ; INSULIN SENSITIVITY ; BILE-ACIDS ; MECHANISMS ; ADAPTATION ; EXPRESSION ; INCREASES ; GLUCOSE ; HUMANS
资助项目Science and Technology Planning Project of Guangdong Province of China[202002020069] ; National Natural Science Foundation of P. R. China[NSFC 82300470]
WOS研究方向Endocrinology & Metabolism
语种英语
WOS记录号WOS:001400998900001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/315875]  
专题中国科学院上海药物研究所
通讯作者Zhang, Hongbin; Wu, Liangping
作者单位1.Guangzhou Hualiang Qingying Biotechnol Co Ltd, Guangzhou, Peoples R China
2.Southern Med Univ, Sch Lab Med & Biotechnol, Guangzhou, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Guangzhou, Peoples R China
4.Southern Med Univ, Dept Cardiovasc Surg, Zhujiang Hosp, Guangzhou, Peoples R China
5.Gen Hosp Southern Theater Command Peoples Liberat, Dept Basic Med Res, Guangzhou, Peoples R China
6.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangzhou, Peoples R China
7.Guangzhou Univ Chinese Med, Dept Metab Surg, Jinshazhou Hosp, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Li, Heng,He, Jipei,Hou, Jie,et al. Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery[J]. FRONTIERS IN ENDOCRINOLOGY,2025,15:13.
APA Li, Heng.,He, Jipei.,Hou, Jie.,He, Chengjun.,Dai, Xiaojiang.,...&Wu, Liangping.(2025).Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery.FRONTIERS IN ENDOCRINOLOGY,15,13.
MLA Li, Heng,et al."Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery".FRONTIERS IN ENDOCRINOLOGY 15(2025):13.

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来源：上海药物研究所

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